Abstract
Cognitive dysfunction is a common feature of schizophrenia and deficits are present before the onset of psychosis, and are moderate to severe by the time of the first episode. Controversy exists over the course of cognitive dysfunction after the first episode. This study examined age-associated differences in performance on clinical neuropsychological (NP) and information processing tasks in a sample of geriatric community living schizophrenia patients (n = 172). Compared to healthy control subjects (n = 70), people with schizophrenia did not differ on NP tests across age groups but showed evidence for age-associated cognitive worsening on the more complex components of an information-processing test. Age-related changes in cognitive function in schizophrenia may be a function of both the course of illness and the processing demands of the cognitive measure of interest. Tests with fixed difficulty, such as clinical NP tests, may differ in their sensitivity from tests for which parametric difficulty manipulations can be performed.
| Original language | English |
|---|---|
| Pages (from-to) | 50-58 |
| Number of pages | 9 |
| Journal | Schizophrenia Research |
| Volume | 106 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 1 2008 |
| Externally published | Yes |
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Keywords
- Aging
- Cognition
- Information processing
- Neuropsychology
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Age-associated differences in cognitive performance in older community dwelling schizophrenia patients : Differential sensitivity of clinical neuropsychological and experimental information processing tests. / Bowie, Christopher R.; Reichenberg, Abraham; McClure, Margaret M.; Leung, Winnie L.; Harvey, Philip D.
In: Schizophrenia Research, Vol. 106, No. 1, 01.11.2008, p. 50-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-associated differences in cognitive performance in older community dwelling schizophrenia patients
T2 - Differential sensitivity of clinical neuropsychological and experimental information processing tests
AU - Bowie, Christopher R.
AU - Reichenberg, Abraham
AU - McClure, Margaret M.
AU - Leung, Winnie L.
AU - Harvey, Philip D
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Cognitive dysfunction is a common feature of schizophrenia and deficits are present before the onset of psychosis, and are moderate to severe by the time of the first episode. Controversy exists over the course of cognitive dysfunction after the first episode. This study examined age-associated differences in performance on clinical neuropsychological (NP) and information processing tasks in a sample of geriatric community living schizophrenia patients (n = 172). Compared to healthy control subjects (n = 70), people with schizophrenia did not differ on NP tests across age groups but showed evidence for age-associated cognitive worsening on the more complex components of an information-processing test. Age-related changes in cognitive function in schizophrenia may be a function of both the course of illness and the processing demands of the cognitive measure of interest. Tests with fixed difficulty, such as clinical NP tests, may differ in their sensitivity from tests for which parametric difficulty manipulations can be performed.
AB - Cognitive dysfunction is a common feature of schizophrenia and deficits are present before the onset of psychosis, and are moderate to severe by the time of the first episode. Controversy exists over the course of cognitive dysfunction after the first episode. This study examined age-associated differences in performance on clinical neuropsychological (NP) and information processing tasks in a sample of geriatric community living schizophrenia patients (n = 172). Compared to healthy control subjects (n = 70), people with schizophrenia did not differ on NP tests across age groups but showed evidence for age-associated cognitive worsening on the more complex components of an information-processing test. Age-related changes in cognitive function in schizophrenia may be a function of both the course of illness and the processing demands of the cognitive measure of interest. Tests with fixed difficulty, such as clinical NP tests, may differ in their sensitivity from tests for which parametric difficulty manipulations can be performed.
KW - Aging
KW - Cognition
KW - Information processing
KW - Neuropsychology
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=54349094606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54349094606&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2007.10.026
DO - 10.1016/j.schres.2007.10.026
M3 - Article
VL - 106
SP - 50
EP - 58
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1
ER -