Abstract
The pharmacokinetics of midazolam were studied in surgical patients given 0.3 mg kg-1 i.v. for either the induction of anaesthesia, or postoperative sedation following cardiopulmonary bypass. The short elimination half-life of midazolam (2.4 h in patients < 50 yr undergoing minor surgery) was significantly, although not markedly, prolonged with age (4.1 h in patients > 50 yr undergoing minor procedures) and by the nature of the operation (3.8 h after major operative procedures). These changes were the result of alterations in clearance and volume of distribution with age, and in volume of distribution with nature of operation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 866-871 |
| Number of pages | 6 |
| Journal | British Journal of Anaesthesia |
| Volume | 57 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1985 |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
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Cite this
Harper, K. W., Collier, P. S., Dundee, J. W., Elliott, P., Halliday, N. J., & Lowry, K. G. (1985). Age and nature of operation influence the pharmacokinetics of midazolam. British Journal of Anaesthesia, 57(9), 866-871. https://doi.org/10.1093/bja/57.9.866