Age and nature of operation influence the pharmacokinetics of midazolam

K. W. Harper; P. S. Collier; J. W. Dundee; P. Elliott; N. J. Halliday; K. G. Lowry

doi:10.1093/bja/57.9.866

Age and nature of operation influence the pharmacokinetics of midazolam

K. W. Harper, P. S. Collier, J. W. Dundee, P. Elliott, N. J. Halliday, K. G. Lowry

Research output: Contribution to journal › Article › peer-review

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Abstract

The pharmacokinetics of midazolam were studied in surgical patients given 0.3 mg kg^-1 i.v. for either the induction of anaesthesia, or postoperative sedation following cardiopulmonary bypass. The short elimination half-life of midazolam (2.4 h in patients < 50 yr undergoing minor surgery) was significantly, although not markedly, prolonged with age (4.1 h in patients > 50 yr undergoing minor procedures) and by the nature of the operation (3.8 h after major operative procedures). These changes were the result of alterations in clearance and volume of distribution with age, and in volume of distribution with nature of operation.

Original language	English (US)
Pages (from-to)	866-871
Number of pages	6
Journal	British Journal of Anaesthesia
Volume	57
Issue number	9
DOIs	https://doi.org/10.1093/bja/57.9.866
State	Published - Sep 1985
Externally published	Yes

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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AU - Collier, P. S.

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AU - Halliday, N. J.

AU - Lowry, K. G.

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AB - The pharmacokinetics of midazolam were studied in surgical patients given 0.3 mg kg-1 i.v. for either the induction of anaesthesia, or postoperative sedation following cardiopulmonary bypass. The short elimination half-life of midazolam (2.4 h in patients < 50 yr undergoing minor surgery) was significantly, although not markedly, prolonged with age (4.1 h in patients > 50 yr undergoing minor procedures) and by the nature of the operation (3.8 h after major operative procedures). These changes were the result of alterations in clearance and volume of distribution with age, and in volume of distribution with nature of operation.

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Age and nature of operation influence the pharmacokinetics of midazolam

Abstract

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