Abstract
The pharmacokinetics of midazolam were studied in surgical patients given 0.3 mg kg-1 i.v. for either the induction of anaesthesia, or postoperative sedation following cardiopulmonary bypass. The short elimination half-life of midazolam (2.4 h in patients < 50 yr undergoing minor surgery) was significantly, although not markedly, prolonged with age (4.1 h in patients > 50 yr undergoing minor procedures) and by the nature of the operation (3.8 h after major operative procedures). These changes were the result of alterations in clearance and volume of distribution with age, and in volume of distribution with nature of operation.
Original language | English (US) |
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Pages (from-to) | 866-871 |
Number of pages | 6 |
Journal | British Journal of Anaesthesia |
Volume | 57 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine