African-American Men with Gleason Score 3+3=6 Prostate Cancer Produce Less Prostate Specific Antigen than Caucasian Men: A Potential Impact on Active Surveillance

Oleksandr Kryvenko, Raymond Balise, Nachiketh Soodana Prakash, Jonathan I. Epstein

Research output: Contribution to journalArticle

17 Scopus citations


Purpose We assess the difference in prostate specific antigen production between African-American and Caucasian men with Gleason score 3+3=6 prostate cancer. Materials and Methods We measured tumor volume in 414 consecutive radical prostatectomies from men with National Comprehensive Cancer Network® low risk prostate cancer (348 Caucasian, 66 African-American) who had Gleason score 3+3=6 disease at radical prostatectomy. We then compared clinical presentation, pathological findings, prostate specific antigen, prostate specific antigen density and prostate specific antigen mass (an absolute amount of prostate specific antigen in patient's circulation) between African-American and Caucasian men. The t-test and Wilcoxon rank sum were used for comparison of means. Results African-American and Caucasian men had similar clinical findings based on age, body mass index and prostate specific antigen. There were no statistically significant differences between the dominant tumor nodule volume and total tumor volume (mean 0.712 vs 0.665 cm3, p=0.695) between African-American and Caucasian men. Prostates were heavier in African-American men (mean 55.4 vs 46.3 gm, p

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalJournal of Urology
Issue number2
StatePublished - Feb 1 2016



  • African Americans
  • European continental ancestry group
  • neoplasm grading
  • prostate-specific antigen
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

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