Abstract
Background: Determine the effect of race, socioeconomic status (SES) and other demographic variables on outcomes of patients with invasive ductal and lobular breast cancer. Study Design: Florida cancer registry and inpatient hospital data were queried for patients diagnosed with invasive breast cancer from 1998 to 2002. Results: A total of 63,472 patients with breast cancer were identified. Overall, 90.5% of patients were Caucasian, 7.6% African American, and 8.7% Hispanic. African-American patients presented at a younger age and with more-advanced disease, 10.5% presented with breast cancer before the age of 40 years, and 22.4% before 45 years of age. African-American patients were less likely to undergo operations. Similarly, low-SES patients were less likely to have operations and presented more often with larger tumors. Stepwise multivariate analysis revealed a substantial drop in the hazard ratio for African-American patients once correction for stage of presentation was made, suggesting that disparities in breast cancer outcomes are, in part, a result of advanced stage at presentation. Race and low SES were independent predictors of worse prognosis when controlling for patient comorbidities and treatment. Conclusions: Dramatic disparities by patient race and SES exist in breast cancer. Our study integrates previous smaller studies, providing comprehensive insight into African-American patients and their outcomes for breast cancer. Earlier screening programs and greater access to cancer care for the poor and African Americans are needed. Successful institution of such programs will not completely erase disparities in outcomes for breast cancer in African-American patients.
| Original language | English |
|---|---|
| Pages (from-to) | 853-868 |
| Number of pages | 16 |
| Journal | Journal of the American College of Surgeons |
| Volume | 208 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2009 |
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ASJC Scopus subject areas
- Surgery
Cite this
African-American and Low-Socioeconomic Status Patients Have a Worse Prognosis for Invasive Ductal and Lobular Breast Carcinoma : Do Screening Criteria Need to Change? / Yang, Relin; Cheung, Michael C.; Franceschi, Dido; Hurley, Judith; Huang, Youjie; Livingstone, Alan; Koniaris, Leonidas G.
In: Journal of the American College of Surgeons, Vol. 208, No. 5, 01.05.2009, p. 853-868.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - African-American and Low-Socioeconomic Status Patients Have a Worse Prognosis for Invasive Ductal and Lobular Breast Carcinoma
T2 - Do Screening Criteria Need to Change?
AU - Yang, Relin
AU - Cheung, Michael C.
AU - Franceschi, Dido
AU - Hurley, Judith
AU - Huang, Youjie
AU - Livingstone, Alan
AU - Koniaris, Leonidas G.
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Background: Determine the effect of race, socioeconomic status (SES) and other demographic variables on outcomes of patients with invasive ductal and lobular breast cancer. Study Design: Florida cancer registry and inpatient hospital data were queried for patients diagnosed with invasive breast cancer from 1998 to 2002. Results: A total of 63,472 patients with breast cancer were identified. Overall, 90.5% of patients were Caucasian, 7.6% African American, and 8.7% Hispanic. African-American patients presented at a younger age and with more-advanced disease, 10.5% presented with breast cancer before the age of 40 years, and 22.4% before 45 years of age. African-American patients were less likely to undergo operations. Similarly, low-SES patients were less likely to have operations and presented more often with larger tumors. Stepwise multivariate analysis revealed a substantial drop in the hazard ratio for African-American patients once correction for stage of presentation was made, suggesting that disparities in breast cancer outcomes are, in part, a result of advanced stage at presentation. Race and low SES were independent predictors of worse prognosis when controlling for patient comorbidities and treatment. Conclusions: Dramatic disparities by patient race and SES exist in breast cancer. Our study integrates previous smaller studies, providing comprehensive insight into African-American patients and their outcomes for breast cancer. Earlier screening programs and greater access to cancer care for the poor and African Americans are needed. Successful institution of such programs will not completely erase disparities in outcomes for breast cancer in African-American patients.
AB - Background: Determine the effect of race, socioeconomic status (SES) and other demographic variables on outcomes of patients with invasive ductal and lobular breast cancer. Study Design: Florida cancer registry and inpatient hospital data were queried for patients diagnosed with invasive breast cancer from 1998 to 2002. Results: A total of 63,472 patients with breast cancer were identified. Overall, 90.5% of patients were Caucasian, 7.6% African American, and 8.7% Hispanic. African-American patients presented at a younger age and with more-advanced disease, 10.5% presented with breast cancer before the age of 40 years, and 22.4% before 45 years of age. African-American patients were less likely to undergo operations. Similarly, low-SES patients were less likely to have operations and presented more often with larger tumors. Stepwise multivariate analysis revealed a substantial drop in the hazard ratio for African-American patients once correction for stage of presentation was made, suggesting that disparities in breast cancer outcomes are, in part, a result of advanced stage at presentation. Race and low SES were independent predictors of worse prognosis when controlling for patient comorbidities and treatment. Conclusions: Dramatic disparities by patient race and SES exist in breast cancer. Our study integrates previous smaller studies, providing comprehensive insight into African-American patients and their outcomes for breast cancer. Earlier screening programs and greater access to cancer care for the poor and African Americans are needed. Successful institution of such programs will not completely erase disparities in outcomes for breast cancer in African-American patients.
UR - http://www.scopus.com/inward/record.url?scp=64949170829&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=64949170829&partnerID=8YFLogxK
U2 - 10.1016/j.jamcollsurg.2008.10.038
DO - 10.1016/j.jamcollsurg.2008.10.038
M3 - Article
C2 - 19476849
AN - SCOPUS:64949170829
VL - 208
SP - 853
EP - 868
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
SN - 1072-7515
IS - 5
ER -