African-American and Low-Socioeconomic Status Patients Have a Worse Prognosis for Invasive Ductal and Lobular Breast Carcinoma: Do Screening Criteria Need to Change?

Relin Yang, Michael C. Cheung, Dido Franceschi, Judith Hurley, Youjie Huang, Alan Livingstone, Leonidas G. Koniaris

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14 Citations (Scopus)

Abstract

Background: Determine the effect of race, socioeconomic status (SES) and other demographic variables on outcomes of patients with invasive ductal and lobular breast cancer. Study Design: Florida cancer registry and inpatient hospital data were queried for patients diagnosed with invasive breast cancer from 1998 to 2002. Results: A total of 63,472 patients with breast cancer were identified. Overall, 90.5% of patients were Caucasian, 7.6% African American, and 8.7% Hispanic. African-American patients presented at a younger age and with more-advanced disease, 10.5% presented with breast cancer before the age of 40 years, and 22.4% before 45 years of age. African-American patients were less likely to undergo operations. Similarly, low-SES patients were less likely to have operations and presented more often with larger tumors. Stepwise multivariate analysis revealed a substantial drop in the hazard ratio for African-American patients once correction for stage of presentation was made, suggesting that disparities in breast cancer outcomes are, in part, a result of advanced stage at presentation. Race and low SES were independent predictors of worse prognosis when controlling for patient comorbidities and treatment. Conclusions: Dramatic disparities by patient race and SES exist in breast cancer. Our study integrates previous smaller studies, providing comprehensive insight into African-American patients and their outcomes for breast cancer. Earlier screening programs and greater access to cancer care for the poor and African Americans are needed. Successful institution of such programs will not completely erase disparities in outcomes for breast cancer in African-American patients.

Original languageEnglish
Pages (from-to)853-868
Number of pages16
JournalJournal of the American College of Surgeons
Volume208
Issue number5
DOIs
StatePublished - May 1 2009

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Lobular Carcinoma
Social Class
African Americans
Breast
Breast Neoplasms
Neoplasms
Hispanic Americans
Registries
Comorbidity
Inpatients

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "African-American and Low-Socioeconomic Status Patients Have a Worse Prognosis for Invasive Ductal and Lobular Breast Carcinoma: Do Screening Criteria Need to Change?",
abstract = "Background: Determine the effect of race, socioeconomic status (SES) and other demographic variables on outcomes of patients with invasive ductal and lobular breast cancer. Study Design: Florida cancer registry and inpatient hospital data were queried for patients diagnosed with invasive breast cancer from 1998 to 2002. Results: A total of 63,472 patients with breast cancer were identified. Overall, 90.5{\%} of patients were Caucasian, 7.6{\%} African American, and 8.7{\%} Hispanic. African-American patients presented at a younger age and with more-advanced disease, 10.5{\%} presented with breast cancer before the age of 40 years, and 22.4{\%} before 45 years of age. African-American patients were less likely to undergo operations. Similarly, low-SES patients were less likely to have operations and presented more often with larger tumors. Stepwise multivariate analysis revealed a substantial drop in the hazard ratio for African-American patients once correction for stage of presentation was made, suggesting that disparities in breast cancer outcomes are, in part, a result of advanced stage at presentation. Race and low SES were independent predictors of worse prognosis when controlling for patient comorbidities and treatment. Conclusions: Dramatic disparities by patient race and SES exist in breast cancer. Our study integrates previous smaller studies, providing comprehensive insight into African-American patients and their outcomes for breast cancer. Earlier screening programs and greater access to cancer care for the poor and African Americans are needed. Successful institution of such programs will not completely erase disparities in outcomes for breast cancer in African-American patients.",
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AU - Cheung, Michael C.

AU - Franceschi, Dido

AU - Hurley, Judith

AU - Huang, Youjie

AU - Livingstone, Alan

AU - Koniaris, Leonidas G.

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