Affective state and thyrotropin and prolactin responses after repeated injections of thyrotropin releasing hormone in depressed patients

R. H. Ehrensing, A. J. Kastin, D. S. Schalch, H. G. Friesen, J. R. Vargas, A. V. Schally

Research output: Contribution to journalArticle

101 Scopus citations


Eight patients with serious depression were given 1000 μg of thyrotropin releasing hormone (TRH) or saline intravenously for three days in a double blind study. All patients then received 1000 μg of TRH daily for the next seven days. The group receiving saline showed the greatest improvement; only one patient improved substantially while receiving TRH. Plasma thyrotropin and prolactin responses to TRH were distinctly diminished in three of the most severely depressed patients. The authors suggest that in depression the primary value of TRH may be as a diagnostic tool in differentiating among various types of depression. l3w1=aw, E10, 12.9.1974, 75/08/14

Original languageEnglish (US)
Pages (from-to)714-718
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number6
StatePublished - Dec 1 1974


ASJC Scopus subject areas

  • Psychiatry and Mental health

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