Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women

Alice S. Ryan, Barbara J. Nicklas, Dora Berman-Weinberg

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: To determine the effects of weight loss (WL) alone and combined with aerobic exercise on visceral adipose tissue (VAT), intramuscular fat, insulin-stimulated glucose uptake, and the rate of decline in free fatty acid (FFA) concentrations during hyperinsulinemia. Research Methods and Procedures: We studied 33 sedentary, obese (BMI = 32 ±1 kg/m2) postmenopausal women who completed a 6-month (three times per week) program of either WL alone (n = 16) or WL + aerobic exercise (AEX) (n = 17). Glucose utilization (M) was measured during a 3-hour hyperinsulinemic-euglycemic clamp (40 mU/m2 per minute). MA, the amount of glucose metabolized per unit of plasma insulin (I), was used as an index of insulin sensitivity. Results: Body weight, total fat mass, and percentage fat decreased similarly in both groups (p < 0.01). VAT, subcutaneous abdominal adipose tissue, mid-thigh subcutaneous fat, and intramuscular fat decreased to a similar extent in both groups and between 14% and 27% after WL and WL+AEX (p < 0.05). WL alone did not change M or M/I; however, M and M/I increased 15% and 21% after WL+AEX (p < 0.05). Fasting concentrations and rate of decline of FFA did not change in either group. In stepwise regression models to determine the independent predictors of changes in M and M/I, the change in VAT was the single independent predictor of M (r2 = 0.30) and M/I (r2 = 0.33). Discussion: Intramuscular fat decreases similarly with 6 months of moderate WL alone or with aerobic exercise in postmenopausal women. In contrast, only WL combined with exercise results in increased glucose utilization and insulin sensitivity. These findings should be validated in a larger population.

Original languageEnglish
Pages (from-to)1064-1072
Number of pages9
JournalObesity
Volume14
Issue number6
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

Fingerprint

Weight Loss
Exercise
Glucose
Fats
Intra-Abdominal Fat
Nonesterified Fatty Acids
Insulin Resistance
Abdominal Subcutaneous Fat
Insulin
Weight Reduction Programs
Glucose Clamp Technique
Subcutaneous Fat
Hyperinsulinism
Thigh
Fasting
Body Weight
Research
Population

Keywords

  • Fat oxidation
  • Insulin resistance
  • Intramuscular fat
  • Visceral fat
  • Weight loss

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women. / Ryan, Alice S.; Nicklas, Barbara J.; Berman-Weinberg, Dora.

In: Obesity, Vol. 14, No. 6, 01.06.2006, p. 1064-1072.

Research output: Contribution to journalArticle

Ryan, Alice S. ; Nicklas, Barbara J. ; Berman-Weinberg, Dora. / Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women. In: Obesity. 2006 ; Vol. 14, No. 6. pp. 1064-1072.
@article{818f51147ee24cfba7b992c42479a8c5,
title = "Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women",
abstract = "Objective: To determine the effects of weight loss (WL) alone and combined with aerobic exercise on visceral adipose tissue (VAT), intramuscular fat, insulin-stimulated glucose uptake, and the rate of decline in free fatty acid (FFA) concentrations during hyperinsulinemia. Research Methods and Procedures: We studied 33 sedentary, obese (BMI = 32 ±1 kg/m2) postmenopausal women who completed a 6-month (three times per week) program of either WL alone (n = 16) or WL + aerobic exercise (AEX) (n = 17). Glucose utilization (M) was measured during a 3-hour hyperinsulinemic-euglycemic clamp (40 mU/m2 per minute). MA, the amount of glucose metabolized per unit of plasma insulin (I), was used as an index of insulin sensitivity. Results: Body weight, total fat mass, and percentage fat decreased similarly in both groups (p < 0.01). VAT, subcutaneous abdominal adipose tissue, mid-thigh subcutaneous fat, and intramuscular fat decreased to a similar extent in both groups and between 14{\%} and 27{\%} after WL and WL+AEX (p < 0.05). WL alone did not change M or M/I; however, M and M/I increased 15{\%} and 21{\%} after WL+AEX (p < 0.05). Fasting concentrations and rate of decline of FFA did not change in either group. In stepwise regression models to determine the independent predictors of changes in M and M/I, the change in VAT was the single independent predictor of M (r2 = 0.30) and M/I (r2 = 0.33). Discussion: Intramuscular fat decreases similarly with 6 months of moderate WL alone or with aerobic exercise in postmenopausal women. In contrast, only WL combined with exercise results in increased glucose utilization and insulin sensitivity. These findings should be validated in a larger population.",
keywords = "Fat oxidation, Insulin resistance, Intramuscular fat, Visceral fat, Weight loss",
author = "Ryan, {Alice S.} and Nicklas, {Barbara J.} and Dora Berman-Weinberg",
year = "2006",
month = "6",
day = "1",
doi = "10.1038/oby.2006.122",
language = "English",
volume = "14",
pages = "1064--1072",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Aerobic exercise is necessary to improve glucose utilization with moderate weight loss in women

AU - Ryan, Alice S.

AU - Nicklas, Barbara J.

AU - Berman-Weinberg, Dora

PY - 2006/6/1

Y1 - 2006/6/1

N2 - Objective: To determine the effects of weight loss (WL) alone and combined with aerobic exercise on visceral adipose tissue (VAT), intramuscular fat, insulin-stimulated glucose uptake, and the rate of decline in free fatty acid (FFA) concentrations during hyperinsulinemia. Research Methods and Procedures: We studied 33 sedentary, obese (BMI = 32 ±1 kg/m2) postmenopausal women who completed a 6-month (three times per week) program of either WL alone (n = 16) or WL + aerobic exercise (AEX) (n = 17). Glucose utilization (M) was measured during a 3-hour hyperinsulinemic-euglycemic clamp (40 mU/m2 per minute). MA, the amount of glucose metabolized per unit of plasma insulin (I), was used as an index of insulin sensitivity. Results: Body weight, total fat mass, and percentage fat decreased similarly in both groups (p < 0.01). VAT, subcutaneous abdominal adipose tissue, mid-thigh subcutaneous fat, and intramuscular fat decreased to a similar extent in both groups and between 14% and 27% after WL and WL+AEX (p < 0.05). WL alone did not change M or M/I; however, M and M/I increased 15% and 21% after WL+AEX (p < 0.05). Fasting concentrations and rate of decline of FFA did not change in either group. In stepwise regression models to determine the independent predictors of changes in M and M/I, the change in VAT was the single independent predictor of M (r2 = 0.30) and M/I (r2 = 0.33). Discussion: Intramuscular fat decreases similarly with 6 months of moderate WL alone or with aerobic exercise in postmenopausal women. In contrast, only WL combined with exercise results in increased glucose utilization and insulin sensitivity. These findings should be validated in a larger population.

AB - Objective: To determine the effects of weight loss (WL) alone and combined with aerobic exercise on visceral adipose tissue (VAT), intramuscular fat, insulin-stimulated glucose uptake, and the rate of decline in free fatty acid (FFA) concentrations during hyperinsulinemia. Research Methods and Procedures: We studied 33 sedentary, obese (BMI = 32 ±1 kg/m2) postmenopausal women who completed a 6-month (three times per week) program of either WL alone (n = 16) or WL + aerobic exercise (AEX) (n = 17). Glucose utilization (M) was measured during a 3-hour hyperinsulinemic-euglycemic clamp (40 mU/m2 per minute). MA, the amount of glucose metabolized per unit of plasma insulin (I), was used as an index of insulin sensitivity. Results: Body weight, total fat mass, and percentage fat decreased similarly in both groups (p < 0.01). VAT, subcutaneous abdominal adipose tissue, mid-thigh subcutaneous fat, and intramuscular fat decreased to a similar extent in both groups and between 14% and 27% after WL and WL+AEX (p < 0.05). WL alone did not change M or M/I; however, M and M/I increased 15% and 21% after WL+AEX (p < 0.05). Fasting concentrations and rate of decline of FFA did not change in either group. In stepwise regression models to determine the independent predictors of changes in M and M/I, the change in VAT was the single independent predictor of M (r2 = 0.30) and M/I (r2 = 0.33). Discussion: Intramuscular fat decreases similarly with 6 months of moderate WL alone or with aerobic exercise in postmenopausal women. In contrast, only WL combined with exercise results in increased glucose utilization and insulin sensitivity. These findings should be validated in a larger population.

KW - Fat oxidation

KW - Insulin resistance

KW - Intramuscular fat

KW - Visceral fat

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=33846867029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846867029&partnerID=8YFLogxK

U2 - 10.1038/oby.2006.122

DO - 10.1038/oby.2006.122

M3 - Article

C2 - 16861612

AN - SCOPUS:33846867029

VL - 14

SP - 1064

EP - 1072

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 6

ER -