Adverse Events after Intravitreal Triamcinolone in Patients with and without Uveitis

Anat Galor, Ron Margolis, Oswaldo M.F. Brasil, Victor L. Perez, Peter K. Kaiser, Jonathan E. Sears, Careen Y. Lowder, Scott D. Smith

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Purpose: To evaluate the rates of adverse ocular events after intravitreal triamcinolone acetonide (IVTA) injection in patients with and without uveitis. Design: Retrospective observational case series. Participants: Two hundred twenty-two eyes of 173 patients were included in the study: 45 eyes of 31 patients with macular edema (ME) due to uveitis and 177 eyes of 142 patients with ME secondary to other etiologies. Methods: Retrospective review of patients who received IVTA at the Cole Eye Institute for ME attributable to various causes between the years 2001 and 2005. Data review of clinical records included patient demographics, etiology of ME, and adverse outcomes after injection. Rates of adverse outcomes in patients with and without uveitis were compared. Main Outcome Measures: Intraocular pressure (IOP) elevation and posterior subcapsular cataract (PSC) progression. Results: Uveitis patients were significantly younger, more likely to be female, and more likely to have had prior posterior sub-Tenon's capsule steroid injection and/or glaucoma therapy than their nonuveitis counterparts. In a multivariate analysis adjusting for the differences in these factors, the presence of uveitis was the strongest risk factor for an adverse IOP event (odds ratio, 2.5; 95% confidence interval [CI], 1.0-6.1; P = 0.05). The odds of having a documented increase in PSC after IVTA injection were 5.6 times greater in uveitis eyes (P = 0.007; 95% CI, 1.6-19.6). Conclusions: Intraocular pressure elevation and PSC progression occurred with greater frequency in uveitis patients receiving IVTA. Patients with uveitis treated with IVTA should be counseled about these risks and monitored closely.

Original languageEnglish (US)
Pages (from-to)1912-1918
Number of pages7
JournalOphthalmology
Volume114
Issue number10
DOIs
StatePublished - Oct 1 2007

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Adverse Events after Intravitreal Triamcinolone in Patients with and without Uveitis'. Together they form a unique fingerprint.

  • Cite this

    Galor, A., Margolis, R., Brasil, O. M. F., Perez, V. L., Kaiser, P. K., Sears, J. E., Lowder, C. Y., & Smith, S. D. (2007). Adverse Events after Intravitreal Triamcinolone in Patients with and without Uveitis. Ophthalmology, 114(10), 1912-1918. https://doi.org/10.1016/j.ophtha.2007.05.037