Abstract
A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.
| Original language | English |
|---|---|
| Pages (from-to) | 704-706 |
| Number of pages | 3 |
| Journal | Chest |
| Volume | 83 |
| Issue number | 4 |
| State | Published - Jan 1 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy. / Fedor, J. M.; Stack, R. S.; Pryor, D. B.; Phillips, H. R.
In: Chest, Vol. 83, No. 4, 01.01.1983, p. 704-706.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy
AU - Fedor, J. M.
AU - Stack, R. S.
AU - Pryor, D. B.
AU - Phillips, H. R.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.
AB - A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.
UR - http://www.scopus.com/inward/record.url?scp=0020505138&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020505138&partnerID=8YFLogxK
M3 - Article
VL - 83
SP - 704
EP - 706
JO - Chest
JF - Chest
SN - 0012-3692
IS - 4
ER -