Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy

J. M. Fedor; R. S. Stack; D. B. Pryor; H. R. Phillips

doi:10.1378/chest.83.4.704

Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy

J. M. Fedor, R. S. Stack, D. B. Pryor, H. R. Phillips

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.

Original language	English (US)
Pages (from-to)	704-706
Number of pages	3
Journal	CHEST
Volume	83
Issue number	4
DOIs	https://doi.org/10.1378/chest.83.4.704
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1378/chest.83.4.704

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title = "Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy",

abstract = "A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.",

author = "Fedor, {J. M.} and Stack, {R. S.} and Pryor, {D. B.} and Phillips, {H. R.}",

note = "Funding Information: This work was supported by the Veterans Administration and in part by grant LM 07003 from the National Library of Medicine and by a grant from the Andrew W. Melon Foundation (D.B.P.). ",

year = "1983",

doi = "10.1378/chest.83.4.704",

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publisher = "American College of Chest Physicians",

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T1 - Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy

AU - Fedor, J. M.

AU - Stack, R. S.

AU - Pryor, D. B.

AU - Phillips, H. R.

N1 - Funding Information: This work was supported by the Veterans Administration and in part by grant LM 07003 from the National Library of Medicine and by a grant from the Andrew W. Melon Foundation (D.B.P.).

PY - 1983

Y1 - 1983

N2 - A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.

AB - A 62-year-old man with obstructive hypertrophic cardiomyopathy was given sublingual nifedipine, 10 mg, during invasive hemodynamic monitoring. After 15 minutes, his left ventricular outflow gradient increased from 22 to 80 mm Hg while arterial pressure fell from 152/70 to 122/64 mm Hg. Left ventricular end-diastolic pressure increased from 15 to 22 mm Hg. These adverse hemodynamic responses may have been a result of vasodilation of the peripheral circulation induced by nifedipine. Thus, some patients with hypertrophic obstructive cardiomyopathy may develop serious hemodynamic compromise when treated with nifedipine.

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Adverse effects of nifedipine therapy on hypertrophic obstructive cardiomyopathy

Abstract

ASJC Scopus subject areas

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