Advantage of Ischemic Preconditioning for Hepatic Resection in Pigs

Jun Kadono, Nobuo Hamada, Mikio Fukueda, Naoki Ishizaki, Mamoru Kaieda, Kentaro Gejima, Seigo Nishida, Kazuo Nakamura, Hiroki Yoshida, Ryuzo Sakata

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Ischemic preconditioning (IP) and intermittent inflow occlusion (IO) have provided beneficial outcomes in hepatic resection. However, comparison of these two procedures against warm hepatic ischemia-reperfusion injury has not been studied enough. Materials and methods: Pigs that had undergone 65% hepatectomy were subjected to Control (120 min continuous ischemia, n = 6), IP (10 min ischemia and 10 min reperfusion, followed by 120 min continuous ischemia, n = 6), and IO (120 min ischemia in the form of eight successive periods of 15 min ischemia and 5 min reperfusion, n = 6). We evaluated hepatocyte injury by aspartate aminotransferase, lactate dehydrogenase and hepaplastin test, hepatic microcirculation by hepatic tissue blood flow (HTBF) and endothelin (ET)-1, inflammatory response by tumor necrosis factor-α (TNF-α), and histopathology after reperfusion. Results: IP prevented hepatocyte injury, HTBF disturbance, and hepatocyte necrosis in histopathology as well as IO. These two groups showed significantly better outcomes than Control. IP produced significantly less ET-1 and TNF-α than IO. Conclusions: IP ameliorated hepatic warm ischemia-reperfusion injury. Furthermore, IP gained more advantages in preventing chemokine production such as ET-1 and inflammatory response over IO. IP could take the place of IO for hepatectomy.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalJournal of Surgical Research
Issue number2
StatePublished - Aug 2006
Externally publishedYes


  • hepatic resection
  • intermittent occlusion
  • ischemia-reperfusion injury
  • ischemic preconditioning

ASJC Scopus subject areas

  • Surgery


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