Advances in vasospasm treatment and prevention

Ricardo J. Komotar, Brad E. Zacharia, Ricky Valhora, J. Mocco, E. Sander Connolly

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Outcome after aSAH depends on several factors, including the severity of the initial event, perioperative medical management, surgical variables, and the incidence of complications. Cerebral vasospasm (CV) is ure to consistently respond to treatment, emphasizing the need for further research into the underlying mechanisms of SAH-induced cerebrovascular dysfunction. To this end, our paper reviews the relevant literature on the main therapies employed for CV after aSAH and discusses possible avenues for future investigations. Current management of this condition consists of maximal medical therapy, including triple H regimen and oral administration of calcium antagonists, followed by endovascular balloon angioplasty and/or injection of vasodilatory agents for refractory cases. As the precise pathophysiology of CV is further elucidated, the development of promising investigational therapies will follow.

Original languageEnglish (US)
Pages (from-to)134-142
Number of pages9
JournalJournal of the Neurological Sciences
Volume261
Issue number1-2
DOIs
StatePublished - Oct 15 2007
Externally publishedYes

Keywords

  • Aneurysmal subarachnoid hemorrhage
  • Endovascular
  • Medical management
  • Therapy
  • Vasospasm

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

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    Komotar, R. J., Zacharia, B. E., Valhora, R., Mocco, J., & Connolly, E. S. (2007). Advances in vasospasm treatment and prevention. Journal of the Neurological Sciences, 261(1-2), 134-142. https://doi.org/10.1016/j.jns.2007.04.046