Advances in understanding itching and scratching: A new era of targeted treatments [version 1; referees: 2 approved]

Kristen M. Sanders, Leigh A. Nattkemper, Gil Yosipovitch

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Chronic itch is a significant health burden with few effective treatments. As such, itch researchers seek to understand the mechanisms behind itch and to find potential targets for treatment. The field of itch research is dynamic, and many advances have been made so far this decade. In particular, major steps forward include the identification of new peripheral and central itch mediators and modulators, the discovery of greater roles for immune cells and glia in itch transmission, and a focus on the brain processing of itching and scratching. Finally, several new therapeutic interventions for itch have shown success in clinical trials.

Original languageEnglish (US)
Article number2042
JournalF1000Research
Volume5
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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