Advances in tissue and organ replacement

Anthony Atala

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Applications of regenerative medicine technology may offer new therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a shortage of donor organs that is worsening yearly as the population ages and new cases of organ failure increase. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. The stem cell field is a rapidly advancing aspect of regenerative medicine as well, and new discoveries here create new options for this type of therapy. For example, therapeutic cloning, in which the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells from the resultant embryo, provides another source of cells for cell-based tissue engineering applications. While stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting, indicating that regenerative medicine holds promise for the future.

Original languageEnglish
Pages (from-to)21-31
Number of pages11
JournalCurrent Stem Cell Research and Therapy
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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Regenerative Medicine
Tissue Engineering
Stem Cells
Tissue Donors
Bioengineering
Pluripotent Stem Cells
Cell Transplantation
Therapeutics
Embryonic Stem Cells
Oocytes
Organism Cloning
Embryonic Structures
Technology
Wounds and Injuries
Research
Population

Keywords

  • Acellular tissue matrices
  • Bladder
  • Cartilage
  • Collagen implants
  • Extracellular matrix
  • Polymer

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Advances in tissue and organ replacement. / Atala, Anthony.

In: Current Stem Cell Research and Therapy, Vol. 3, No. 1, 01.01.2008, p. 21-31.

Research output: Contribution to journalArticle

Atala, Anthony. / Advances in tissue and organ replacement. In: Current Stem Cell Research and Therapy. 2008 ; Vol. 3, No. 1. pp. 21-31.
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