Abstract
Context.-Etiologic factors and pathways leading to altered podocyte phenotype are clearly numerous and involve the activity of different cellular function. Objective.-To focus on recent discoveries in podocyte biology and genetics and their relevance to these human glomerular diseases, named podocytopathies. Data Sources.-Genetic mutations in genes encoding for proteins in the nucleus, slit diaphragm, podocyte cytoplasm, and cell membrane are responsible for podocyte phenotype and functional abnormalities. Podocyte injury may also derive from secondary stimuli, such as mechanical stress, infections, or use of certain medications. Podo cytes can respond to injury in a limited number of ways, which include (1) effacement, (2) apoptosis, (3) arrest of development, and (4) dedifferentiation. Each of these pathways results in a specific glomerular morphology: minimal change nephropathy, focal segmental glomerulosclerosis, diffuse mesangial sclerosis, and collapsing glomerulopathy. Conclusions.-Based on current knowledge of podocyte biology, we organized etiologic factors and morphologic features in a taxonomy of podocytopathies, which provides a novel approach to the classification of these diseases. Current and experimental therapeutic approaches are also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 201-216 |
| Number of pages | 16 |
| Journal | Archives of Pathology and Laboratory Medicine |
| Volume | 133 |
| Issue number | 2 |
| State | Published - Feb 1 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology
Cite this
Advances in the biology and genetics of the podocytopathies implications for diagnosis and therapy. / Barisoni-Thomas, Laura; Schnaper, H. William; Kopp, Jeffrey B.
In: Archives of Pathology and Laboratory Medicine, Vol. 133, No. 2, 01.02.2009, p. 201-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Advances in the biology and genetics of the podocytopathies implications for diagnosis and therapy
AU - Barisoni-Thomas, Laura
AU - Schnaper, H. William
AU - Kopp, Jeffrey B.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Context.-Etiologic factors and pathways leading to altered podocyte phenotype are clearly numerous and involve the activity of different cellular function. Objective.-To focus on recent discoveries in podocyte biology and genetics and their relevance to these human glomerular diseases, named podocytopathies. Data Sources.-Genetic mutations in genes encoding for proteins in the nucleus, slit diaphragm, podocyte cytoplasm, and cell membrane are responsible for podocyte phenotype and functional abnormalities. Podocyte injury may also derive from secondary stimuli, such as mechanical stress, infections, or use of certain medications. Podo cytes can respond to injury in a limited number of ways, which include (1) effacement, (2) apoptosis, (3) arrest of development, and (4) dedifferentiation. Each of these pathways results in a specific glomerular morphology: minimal change nephropathy, focal segmental glomerulosclerosis, diffuse mesangial sclerosis, and collapsing glomerulopathy. Conclusions.-Based on current knowledge of podocyte biology, we organized etiologic factors and morphologic features in a taxonomy of podocytopathies, which provides a novel approach to the classification of these diseases. Current and experimental therapeutic approaches are also discussed.
AB - Context.-Etiologic factors and pathways leading to altered podocyte phenotype are clearly numerous and involve the activity of different cellular function. Objective.-To focus on recent discoveries in podocyte biology and genetics and their relevance to these human glomerular diseases, named podocytopathies. Data Sources.-Genetic mutations in genes encoding for proteins in the nucleus, slit diaphragm, podocyte cytoplasm, and cell membrane are responsible for podocyte phenotype and functional abnormalities. Podocyte injury may also derive from secondary stimuli, such as mechanical stress, infections, or use of certain medications. Podo cytes can respond to injury in a limited number of ways, which include (1) effacement, (2) apoptosis, (3) arrest of development, and (4) dedifferentiation. Each of these pathways results in a specific glomerular morphology: minimal change nephropathy, focal segmental glomerulosclerosis, diffuse mesangial sclerosis, and collapsing glomerulopathy. Conclusions.-Based on current knowledge of podocyte biology, we organized etiologic factors and morphologic features in a taxonomy of podocytopathies, which provides a novel approach to the classification of these diseases. Current and experimental therapeutic approaches are also discussed.
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M3 - Article
C2 - 19195964
AN - SCOPUS:60149107051
VL - 133
SP - 201
EP - 216
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
SN - 0003-9985
IS - 2
ER -