Advances in pancreas transplantation

George W. Burke, Gaetano Ciancio, Hans W. Sollinger

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Despite early obstacles impacting the success of pancreatic transplantation, the introduction of new procedures and new immunosuppressive therapies during the past 2 decades has improved outcomes for pancreatic transplant recipients. For example, the use of bladder drainage and better human leukocyte antigen matching has helped overcome some of the early obstacles of pancreatic transplantation. In addition, the introduction of tacrolimus in 1994 and mycophenolate mofetil in 1996 has helped lower rates of acute rejection and increase graft survival, with less nephrotoxicity than treatment with cyclosporine. Regimens allowing the tapering of corticosteroids have also helped reduce the rates of acute pancreas rejection. To further improve therapeutic options for patients with type 1 diabetes or end-stage renal disease, pancreatic islet transplantation and organ and islet xenotransplantation should be further explored.

Original languageEnglish (US)
Pages (from-to)S62-S67
JournalTransplantation
Volume77
Issue number9
DOIs
StatePublished - May 15 2004

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ASJC Scopus subject areas

  • Transplantation

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