Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation

Victor M. Villegas, Aaron S. Gold, Audina Berrocal, Timothy G. Murray

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: To evaluate the impact of intravitreal bevacizumab combined with laser vascular ablation in the management of advanced Coats' disease presenting with exudative retinal detachment. Methods: This was a retrospective review of 24 children that presented with exudative retinal detachments associated with advanced Coats' disease. Mean patient age was 62 months (range 9-160 months). Presenting signs included retinal detachment in 24 children (100%), vascular telangiectasia in 24 children (100%), and retinal ischemia in 24 children (100%). Twenty of 24 children presented with elevated, vascular leakage in the fovea (83%). Two children presented with sub-retinal fibrosis associated with presumed long-standing retinal detachment without evidence of rhegmatogenous retinal detachment. Ten patients exhibited vascular alterations in the periphery of the second eye without clinical evidence of exudation. All 24 children were treated with a large-spot-size diode laser directly to areas of abnormal telangiectatic vasculature. All 24 children received intravitreal bevacizumab injection. Results: All 24 children had resolution of exudative retinal detachment, ablation of vascular telangiectasia, and anatomic improvement of the retina. No child exhibited progressive retinal detachment and no eye required enucleation. No cases of neovascular glaucoma were seen. Fellow eyes with peripheral vascular alterations showed no progression to exudative vasculopathy during the observation period. Intravitreal bevacizumab injection was not associated with endophthalmitis or systemically-observed complications. Conclusion: Repetitive intravitreal bevacizumab combined with laser vascular ablation may be utilized effectively for advanced Coats' disease presenting with exudative retinal detachment.

Original languageEnglish
Pages (from-to)973-976
Number of pages4
JournalClinical Ophthalmology
Volume8
DOIs
StatePublished - May 16 2014

Fingerprint

Retinal Telangiectasis
Laser Therapy
Blood Vessels
Retinal Detachment
Telangiectasis
Intravitreal Injections
Eye Enucleation
Bevacizumab
Neovascular Glaucoma
Semiconductor Lasers
Endophthalmitis
Retina
Fibrosis
Ischemia

Keywords

  • Anti-VEGF
  • Bevacizumab
  • Coats' disease
  • Laser ablation
  • Retina

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation. / Villegas, Victor M.; Gold, Aaron S.; Berrocal, Audina; Murray, Timothy G.

In: Clinical Ophthalmology, Vol. 8, 16.05.2014, p. 973-976.

Research output: Contribution to journalArticle

Villegas, Victor M. ; Gold, Aaron S. ; Berrocal, Audina ; Murray, Timothy G. / Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation. In: Clinical Ophthalmology. 2014 ; Vol. 8. pp. 973-976.
@article{ef690fb9c56848379dd8edf1e3dc152c,
title = "Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation",
abstract = "Purpose: To evaluate the impact of intravitreal bevacizumab combined with laser vascular ablation in the management of advanced Coats' disease presenting with exudative retinal detachment. Methods: This was a retrospective review of 24 children that presented with exudative retinal detachments associated with advanced Coats' disease. Mean patient age was 62 months (range 9-160 months). Presenting signs included retinal detachment in 24 children (100{\%}), vascular telangiectasia in 24 children (100{\%}), and retinal ischemia in 24 children (100{\%}). Twenty of 24 children presented with elevated, vascular leakage in the fovea (83{\%}). Two children presented with sub-retinal fibrosis associated with presumed long-standing retinal detachment without evidence of rhegmatogenous retinal detachment. Ten patients exhibited vascular alterations in the periphery of the second eye without clinical evidence of exudation. All 24 children were treated with a large-spot-size diode laser directly to areas of abnormal telangiectatic vasculature. All 24 children received intravitreal bevacizumab injection. Results: All 24 children had resolution of exudative retinal detachment, ablation of vascular telangiectasia, and anatomic improvement of the retina. No child exhibited progressive retinal detachment and no eye required enucleation. No cases of neovascular glaucoma were seen. Fellow eyes with peripheral vascular alterations showed no progression to exudative vasculopathy during the observation period. Intravitreal bevacizumab injection was not associated with endophthalmitis or systemically-observed complications. Conclusion: Repetitive intravitreal bevacizumab combined with laser vascular ablation may be utilized effectively for advanced Coats' disease presenting with exudative retinal detachment.",
keywords = "Anti-VEGF, Bevacizumab, Coats' disease, Laser ablation, Retina",
author = "Villegas, {Victor M.} and Gold, {Aaron S.} and Audina Berrocal and Murray, {Timothy G.}",
year = "2014",
month = "5",
day = "16",
doi = "10.2147/OPTH.S62816",
language = "English",
volume = "8",
pages = "973--976",
journal = "Clinical Ophthalmology",
issn = "1177-5467",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Advanced Coats' disease treated with intravitreal bevacizumab combined with laser vascular ablation

AU - Villegas, Victor M.

AU - Gold, Aaron S.

AU - Berrocal, Audina

AU - Murray, Timothy G.

PY - 2014/5/16

Y1 - 2014/5/16

N2 - Purpose: To evaluate the impact of intravitreal bevacizumab combined with laser vascular ablation in the management of advanced Coats' disease presenting with exudative retinal detachment. Methods: This was a retrospective review of 24 children that presented with exudative retinal detachments associated with advanced Coats' disease. Mean patient age was 62 months (range 9-160 months). Presenting signs included retinal detachment in 24 children (100%), vascular telangiectasia in 24 children (100%), and retinal ischemia in 24 children (100%). Twenty of 24 children presented with elevated, vascular leakage in the fovea (83%). Two children presented with sub-retinal fibrosis associated with presumed long-standing retinal detachment without evidence of rhegmatogenous retinal detachment. Ten patients exhibited vascular alterations in the periphery of the second eye without clinical evidence of exudation. All 24 children were treated with a large-spot-size diode laser directly to areas of abnormal telangiectatic vasculature. All 24 children received intravitreal bevacizumab injection. Results: All 24 children had resolution of exudative retinal detachment, ablation of vascular telangiectasia, and anatomic improvement of the retina. No child exhibited progressive retinal detachment and no eye required enucleation. No cases of neovascular glaucoma were seen. Fellow eyes with peripheral vascular alterations showed no progression to exudative vasculopathy during the observation period. Intravitreal bevacizumab injection was not associated with endophthalmitis or systemically-observed complications. Conclusion: Repetitive intravitreal bevacizumab combined with laser vascular ablation may be utilized effectively for advanced Coats' disease presenting with exudative retinal detachment.

AB - Purpose: To evaluate the impact of intravitreal bevacizumab combined with laser vascular ablation in the management of advanced Coats' disease presenting with exudative retinal detachment. Methods: This was a retrospective review of 24 children that presented with exudative retinal detachments associated with advanced Coats' disease. Mean patient age was 62 months (range 9-160 months). Presenting signs included retinal detachment in 24 children (100%), vascular telangiectasia in 24 children (100%), and retinal ischemia in 24 children (100%). Twenty of 24 children presented with elevated, vascular leakage in the fovea (83%). Two children presented with sub-retinal fibrosis associated with presumed long-standing retinal detachment without evidence of rhegmatogenous retinal detachment. Ten patients exhibited vascular alterations in the periphery of the second eye without clinical evidence of exudation. All 24 children were treated with a large-spot-size diode laser directly to areas of abnormal telangiectatic vasculature. All 24 children received intravitreal bevacizumab injection. Results: All 24 children had resolution of exudative retinal detachment, ablation of vascular telangiectasia, and anatomic improvement of the retina. No child exhibited progressive retinal detachment and no eye required enucleation. No cases of neovascular glaucoma were seen. Fellow eyes with peripheral vascular alterations showed no progression to exudative vasculopathy during the observation period. Intravitreal bevacizumab injection was not associated with endophthalmitis or systemically-observed complications. Conclusion: Repetitive intravitreal bevacizumab combined with laser vascular ablation may be utilized effectively for advanced Coats' disease presenting with exudative retinal detachment.

KW - Anti-VEGF

KW - Bevacizumab

KW - Coats' disease

KW - Laser ablation

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=84901307059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901307059&partnerID=8YFLogxK

U2 - 10.2147/OPTH.S62816

DO - 10.2147/OPTH.S62816

M3 - Article

AN - SCOPUS:84901307059

VL - 8

SP - 973

EP - 976

JO - Clinical Ophthalmology

JF - Clinical Ophthalmology

SN - 1177-5467

ER -