Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin

A clinicopathologic study

Mitsuru Setoyama, Yoshihiko Katahira, Tamotsu Kanzaki, Francisco A. Kerdel, John Byrnes

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume19
Issue number6
DOIs
StatePublished - Dec 12 1997

Fingerprint

Adult T Cell Leukemia Lymphoma
Granuloma
Skin
Epithelioid Cells
Human T-lymphotropic virus 1
Hodgkin Disease
Non-Hodgkin's Lymphoma
Disease Progression
Lymphoma
Lymph Nodes
Lymphocytes
Viruses
Biopsy
Survival

Keywords

  • Adult T-cell leukemia/lymphoma (ATLL)
  • Cutaneous-type ATLL
  • Epithelioid granuloma
  • Favorable prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin : A clinicopathologic study. / Setoyama, Mitsuru; Katahira, Yoshihiko; Kanzaki, Tamotsu; Kerdel, Francisco A.; Byrnes, John.

In: American Journal of Dermatopathology, Vol. 19, No. 6, 12.12.1997, p. 591-595.

Research output: Contribution to journalArticle

Setoyama, Mitsuru ; Katahira, Yoshihiko ; Kanzaki, Tamotsu ; Kerdel, Francisco A. ; Byrnes, John. / Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin : A clinicopathologic study. In: American Journal of Dermatopathology. 1997 ; Vol. 19, No. 6. pp. 591-595.
@article{0572efdb3ee74b7f88620e6c4bc00c99,
title = "Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin: A clinicopathologic study",
abstract = "Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.",
keywords = "Adult T-cell leukemia/lymphoma (ATLL), Cutaneous-type ATLL, Epithelioid granuloma, Favorable prognosis",
author = "Mitsuru Setoyama and Yoshihiko Katahira and Tamotsu Kanzaki and Kerdel, {Francisco A.} and John Byrnes",
year = "1997",
month = "12",
day = "12",
doi = "10.1097/00000372-199712000-00007",
language = "English",
volume = "19",
pages = "591--595",
journal = "American Journal of Dermatopathology",
issn = "0193-1091",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin

T2 - A clinicopathologic study

AU - Setoyama, Mitsuru

AU - Katahira, Yoshihiko

AU - Kanzaki, Tamotsu

AU - Kerdel, Francisco A.

AU - Byrnes, John

PY - 1997/12/12

Y1 - 1997/12/12

N2 - Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.

AB - Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.

KW - Adult T-cell leukemia/lymphoma (ATLL)

KW - Cutaneous-type ATLL

KW - Epithelioid granuloma

KW - Favorable prognosis

UR - http://www.scopus.com/inward/record.url?scp=0030730669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030730669&partnerID=8YFLogxK

U2 - 10.1097/00000372-199712000-00007

DO - 10.1097/00000372-199712000-00007

M3 - Article

VL - 19

SP - 591

EP - 595

JO - American Journal of Dermatopathology

JF - American Journal of Dermatopathology

SN - 0193-1091

IS - 6

ER -