Abstract
Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.
| Original language | English |
|---|---|
| Pages (from-to) | 591-595 |
| Number of pages | 5 |
| Journal | American Journal of Dermatopathology |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 12 1997 |
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Keywords
- Adult T-cell leukemia/lymphoma (ATLL)
- Cutaneous-type ATLL
- Epithelioid granuloma
- Favorable prognosis
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Dermatology
Cite this
Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin : A clinicopathologic study. / Setoyama, Mitsuru; Katahira, Yoshihiko; Kanzaki, Tamotsu; Kerdel, Francisco A.; Byrnes, John.
In: American Journal of Dermatopathology, Vol. 19, No. 6, 12.12.1997, p. 591-595.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin
T2 - A clinicopathologic study
AU - Setoyama, Mitsuru
AU - Katahira, Yoshihiko
AU - Kanzaki, Tamotsu
AU - Kerdel, Francisco A.
AU - Byrnes, John
PY - 1997/12/12
Y1 - 1997/12/12
N2 - Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.
AB - Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.
KW - Adult T-cell leukemia/lymphoma (ATLL)
KW - Cutaneous-type ATLL
KW - Epithelioid granuloma
KW - Favorable prognosis
UR - http://www.scopus.com/inward/record.url?scp=0030730669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030730669&partnerID=8YFLogxK
U2 - 10.1097/00000372-199712000-00007
DO - 10.1097/00000372-199712000-00007
M3 - Article
C2 - 9415616
AN - SCOPUS:0030730669
VL - 19
SP - 591
EP - 595
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 6
ER -