Adult T-cell leukemia/lymphoma associated with noninfectious epithelioid granuloma in the skin: A clinicopathologic study

Mitsuru Setoyama, Yoshihiko Katahira, Tamotsu Kanzaki, Francisco A. Kerdel, John J. Byrnes

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) are infrequently associated with noninfectious granulomas in involved or noninvolved organs. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive lymphoproliferative neoplasm associated with T-lymphotropic virus type 1 (HTLV-1). We describe a case of cutaneous type ATLL, affecting mainly the skin as a maculopapular eruption, in which some skin biopsies contained epithelioid cell granulomas in the lymphoma cutis (ATLL) lesion. These Lennert's-like epithelioid clusters were also present in lymph nodes, which showed some degree of invasion by the ATLL lymphocytes. Although prognosis of ATLL is generally poor, our patient has had a less aggressive course, with a survival time to date of 13 years. Our findings suggest that the presence of epithelioid granulomata in an ATLL patient may be a manifestation of a host response which confers some protection against the disease progression. To our knowledge, this is the first report of a case of ATLL with a noninfectious granuloma similar to a Lennert's lesion.

Original languageEnglish (US)
Pages (from-to)591-595
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume19
Issue number6
DOIs
StatePublished - Dec 12 1997

Keywords

  • Adult T-cell leukemia/lymphoma (ATLL)
  • Cutaneous-type ATLL
  • Epithelioid granuloma
  • Favorable prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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