Adult stem cells for cardiac tissue engineering

Eliana C. Martinez, Theo Kofidis

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Cell therapy and tissue engineering attract increasing attention as a potential approach for cardiac repair. Adult stem cells from autologous origin are a practically safe and appealing source for cell-based regenerative therapies that may hold realistic clinical potential. A plethora of interesting concepts have been introduced aiming at regenerating ischemic myocardium through adult stem cell-based bioartificial cardiac tissue supplements. Yet, current pre-clinical concepts have not reached translational applicability, and successes are only episodic. This review will provide a brief overview of the latest concepts and breakthroughs in the emerging field of cardiac adult stem cell-based tissue engineering, and discuses the challenges that this field needs to overcome to achieve realistic therapeutic translation into the clinical arena. This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited".

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume50
Issue number2
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

Keywords

  • Adult stem cells
  • Heart failure
  • Myocardial ischemia
  • Myocardial restoration
  • Tissue engineering

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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