Adult-onset foveomacular pigment epithelial dystrophy

Clinicopathologic correlation of three cases

Sander Dubovy, R. J. Hairston, H. Schatz, A. P. Schachat, N. M. Bressler, D. Finkelstein, W. R. Green

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Purpose: The authors describe the clinicopathologic features of three patients with adult onset foveomacular pigment epithelial dystrophy (AOFPED). Methods: The eyes of three patients were studied ophthalmoscopically and by fluorescein angiography, and obtained postmortem and studied by light and electron microscopy. Results: Histopathologic study of the three patient's eyes disclosed central loss of the retinal pigment epithelium and photoreceptor cell layer with a moderate number of pigment-containing macrophages present in the subretinal space and outer retina. To either side, the retinal pigment epithelium was distended with much lipofuscin. Basal laminar and basal linear deposits were present throughout the central area. No discontinuities of Bruch membrane were present. Conclusion: The findings in the eyes of three patients with AOFPED included marked aging changes that are similar to those seen in age-related macular degeneration. Pigmented cells with lipofuscin in the subretinal space account for the vitelliform appearance.

Original languageEnglish
Pages (from-to)638-649
Number of pages12
JournalRetina
Volume20
Issue number6
StatePublished - Dec 1 2000
Externally publishedYes

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Lipofuscin
Retinal Pigment Epithelium
Bruch Membrane
Photoreceptor Cells
Vertebrate Photoreceptor Cells
Fluorescein Angiography
Macular Degeneration
Retina
Electron Microscopy
Macrophages
Light

Keywords

  • Adult onset foveomacular pigment epithelial dystrophy
  • Clinicopathologic study

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Dubovy, S., Hairston, R. J., Schatz, H., Schachat, A. P., Bressler, N. M., Finkelstein, D., & Green, W. R. (2000). Adult-onset foveomacular pigment epithelial dystrophy: Clinicopathologic correlation of three cases. Retina, 20(6), 638-649.

Adult-onset foveomacular pigment epithelial dystrophy : Clinicopathologic correlation of three cases. / Dubovy, Sander; Hairston, R. J.; Schatz, H.; Schachat, A. P.; Bressler, N. M.; Finkelstein, D.; Green, W. R.

In: Retina, Vol. 20, No. 6, 01.12.2000, p. 638-649.

Research output: Contribution to journalArticle

Dubovy, S, Hairston, RJ, Schatz, H, Schachat, AP, Bressler, NM, Finkelstein, D & Green, WR 2000, 'Adult-onset foveomacular pigment epithelial dystrophy: Clinicopathologic correlation of three cases', Retina, vol. 20, no. 6, pp. 638-649.
Dubovy S, Hairston RJ, Schatz H, Schachat AP, Bressler NM, Finkelstein D et al. Adult-onset foveomacular pigment epithelial dystrophy: Clinicopathologic correlation of three cases. Retina. 2000 Dec 1;20(6):638-649.
Dubovy, Sander ; Hairston, R. J. ; Schatz, H. ; Schachat, A. P. ; Bressler, N. M. ; Finkelstein, D. ; Green, W. R. / Adult-onset foveomacular pigment epithelial dystrophy : Clinicopathologic correlation of three cases. In: Retina. 2000 ; Vol. 20, No. 6. pp. 638-649.
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