TY - JOUR
T1 - Adult growth hormone deficiency - benefits, side effects, and risks of growth hormone replacement
AU - Reed, Mary L.
AU - Merriam, George R.
AU - Kargi, Atil Y.
PY - 2013
Y1 - 2013
N2 - Deficiency of growth hormone (GH) in adults results in a syndrome characterized by decreased muscle mass and exercise capacity, increased visceral fat, impaired quality of life, unfavorable alterations in lipid profile and markers of cardiovascular risk, decrease in bone mass and integrity, and increased mortality. When dosed appropriately, GH replacement therapy (GHRT) is well tolerated, with a low incidence of side effects, and improves most of the alterations observed in GH deficiency (GHD); beneficial effects on mortality, cardiovascular events, and fracture rates, however, remain to be conclusively demonstrated. The potential of GH to act as a mitogen has resulted in concern over the possibility of increased de novo tumors or recurrence of pre-existing malignancies in individuals treated with GH. Though studies of adults who received GHRT in childhood have produced conflicting reports in this regard, longterm surveillance of adult GHRT has not demonstrated increased cancer risk or mortality.
AB - Deficiency of growth hormone (GH) in adults results in a syndrome characterized by decreased muscle mass and exercise capacity, increased visceral fat, impaired quality of life, unfavorable alterations in lipid profile and markers of cardiovascular risk, decrease in bone mass and integrity, and increased mortality. When dosed appropriately, GH replacement therapy (GHRT) is well tolerated, with a low incidence of side effects, and improves most of the alterations observed in GH deficiency (GHD); beneficial effects on mortality, cardiovascular events, and fracture rates, however, remain to be conclusively demonstrated. The potential of GH to act as a mitogen has resulted in concern over the possibility of increased de novo tumors or recurrence of pre-existing malignancies in individuals treated with GH. Though studies of adults who received GHRT in childhood have produced conflicting reports in this regard, longterm surveillance of adult GHRT has not demonstrated increased cancer risk or mortality.
KW - Adult growth hormone deficiency
KW - Growth hormone
KW - Growth hormone risks
KW - Growth hormone treatment
KW - IGF-I
KW - Insulin-like growth factor-I
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U2 - 10.3389/fendo.2013.00064
DO - 10.3389/fendo.2013.00064
M3 - Review article
C2 - 23761782
AN - SCOPUS:84884190753
VL - 4
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
IS - JUN
M1 - Article 64
ER -