Adrenomedullin as a cytokine

Alexis Elias Malavazos, Gianluca Iacobellis

Research output: Chapter in Book/Report/Conference proceedingChapter


In the last few years, adipose tissue (AT) has been widely investigated and has been revealed to act as a real endocrine organ, secreting various active biomolecules named adipokines, involved in the development of obesity-related diseases. One of these molecules is adrenomedullin, a cytokine expressed in many different cellular types that has been reported to regulate renal function, neurotransmission, and cellular proliferation and also to suppress insulin secretion and oxidative stress, in addition to its vasoactive and hypotensive properties. In particular, it has a crucial role in the adipose tissue, where it appears to be related to the lipidic metabolism, pathophysiology of obesity and obesity-related diseases, through insulin secretion, hypoxia and inflammation, which are the main up-regulators of adrenomedullin release. Adrenomedullin is also related to multiple metabolic factors such as insulin resistance (IR) and diabetes mellitus, C reactive protein, LDL cholesterol, adiponectin and basal microcirculatory perfusion. Furthermore, it has been recently suggested that adrenomedullin, synthesized by the epicardial fat (EF), which is the visceral heart fat depot along the distribution of the coronary arteries, could also exert a protective action to the heart, through its vasodilator and antioxidative actions. It is therefore possible to consider adrenomedullin as an interesting target for investigation because of its vascular implications.

Original languageEnglish (US)
Title of host publicationAdipokines
PublisherCRC Press
Number of pages8
ISBN (Electronic)9781439879887
ISBN (Print)9781138114418
StatePublished - Apr 19 2016
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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