Adrenergic and cholinergic receptors of cerebral microvessels

S. I. Harik, V. K. Sharma, J. R. Wetherbee, R. H. Warren, S. P. Banerjee

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

The presence of α- and β-adrenergic and muscarininc cholinergic receptors in cerebral microvessels of the rat and pig was assessed by ligand binding techniques. The results demonstrate the presence of specific binding to α2- and β-adrenergic receptors but no appreciable specific binding to α1- adrenergic or muscarinic cholinergic receptors. β-Adrenergic receptors of pig cerebral microvessels are similar to those of the brain and other organs in their binding characteristics to the tritiated ligand and in their stereospecificity of binding to the biologically active isomers of β-adrenergic agonists. Further evidence derived from the differential potency of binding displacement by the various β-adrenergic agonists and selective β1 and β2-adrenergic antagonists antagonisits indicates tht β-adrenergic receptors of pig cerebral microvessels are mostly of the β2-subtype.

Original languageEnglish (US)
Pages (from-to)329-338
Number of pages10
JournalUnknown Journal
Volume1
Issue number3
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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