Adrenergic and cholinergic blockade of cardiovascular responses to subcortical electrical stimulation in unanesthetized rabbits

D. A. Powell, S. R. Goldberg, G. W. Dauth, E. Schneiderman, N. Schneiderman

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Unanesthetized rabbits received high frequency, short pulse-train duration electrical stimulation of septal region and hypothalamic locations at current intensities producing blood pressure (BP) increases accompanied by heart rate (HR) decreases. Dose-response and time-response effects were obtained for the HR and BP changes following stimulation under alpha-adrenergic (phentolamine), beta-adrenergic (propranolol) and cholinergic (atropine methylnitrate, atropine sulfate) blocking agents. By examining the relationship of BP and HR changes during stimulation under graded doses of the blocking agents, the HR decreases were shown to be mainly reflex responses to sympathetically-induced BP increases.

Original languageEnglish (US)
Pages (from-to)927-936
Number of pages10
JournalPhysiology AND Behavior
Volume8
Issue number5
DOIs
StatePublished - May 1972

Keywords

  • Alpha-adrenergic blockade
  • Atropine
  • Beta-adrenergic blockade
  • Blood pressure
  • Heart rate
  • Rabbits
  • Subcortical electrical stimulation

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

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