Adrenergic and cholinergic blockade of cardiovascular responses to subcortical electrical stimulation in unanesthetized rabbits

D. A. Powell, S. R. Goldberg, G. W. Dauth, E. Schneiderman, Neil Schneiderman

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Unanesthetized rabbits received high frequency, short pulse-train duration electrical stimulation of septal region and hypothalamic locations at current intensities producing blood pressure (BP) increases accompanied by heart rate (HR) decreases. Dose-response and time-response effects were obtained for the HR and BP changes following stimulation under alpha-adrenergic (phentolamine), beta-adrenergic (propranolol) and cholinergic (atropine methylnitrate, atropine sulfate) blocking agents. By examining the relationship of BP and HR changes during stimulation under graded doses of the blocking agents, the HR decreases were shown to be mainly reflex responses to sympathetically-induced BP increases.

Original languageEnglish
Pages (from-to)927-936
Number of pages10
JournalPhysiology and Behavior
Volume8
Issue number5
DOIs
StatePublished - Jan 1 1972

Fingerprint

Adrenergic Agents
Cholinergic Agents
Electric Stimulation
Heart Rate
Rabbits
Blood Pressure
Atropine
Septum of Brain
Phentolamine
Propranolol
Reaction Time
Reflex

Keywords

  • Alpha-adrenergic blockade
  • Atropine
  • Beta-adrenergic blockade
  • Blood pressure
  • Heart rate
  • Rabbits
  • Subcortical electrical stimulation

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Adrenergic and cholinergic blockade of cardiovascular responses to subcortical electrical stimulation in unanesthetized rabbits. / Powell, D. A.; Goldberg, S. R.; Dauth, G. W.; Schneiderman, E.; Schneiderman, Neil.

In: Physiology and Behavior, Vol. 8, No. 5, 01.01.1972, p. 927-936.

Research output: Contribution to journalArticle

@article{32612965f63142248fd0c914acf66d43,
title = "Adrenergic and cholinergic blockade of cardiovascular responses to subcortical electrical stimulation in unanesthetized rabbits",
abstract = "Unanesthetized rabbits received high frequency, short pulse-train duration electrical stimulation of septal region and hypothalamic locations at current intensities producing blood pressure (BP) increases accompanied by heart rate (HR) decreases. Dose-response and time-response effects were obtained for the HR and BP changes following stimulation under alpha-adrenergic (phentolamine), beta-adrenergic (propranolol) and cholinergic (atropine methylnitrate, atropine sulfate) blocking agents. By examining the relationship of BP and HR changes during stimulation under graded doses of the blocking agents, the HR decreases were shown to be mainly reflex responses to sympathetically-induced BP increases.",
keywords = "Alpha-adrenergic blockade, Atropine, Beta-adrenergic blockade, Blood pressure, Heart rate, Rabbits, Subcortical electrical stimulation",
author = "Powell, {D. A.} and Goldberg, {S. R.} and Dauth, {G. W.} and E. Schneiderman and Neil Schneiderman",
year = "1972",
month = "1",
day = "1",
doi = "10.1016/0031-9384(72)90306-X",
language = "English",
volume = "8",
pages = "927--936",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Adrenergic and cholinergic blockade of cardiovascular responses to subcortical electrical stimulation in unanesthetized rabbits

AU - Powell, D. A.

AU - Goldberg, S. R.

AU - Dauth, G. W.

AU - Schneiderman, E.

AU - Schneiderman, Neil

PY - 1972/1/1

Y1 - 1972/1/1

N2 - Unanesthetized rabbits received high frequency, short pulse-train duration electrical stimulation of septal region and hypothalamic locations at current intensities producing blood pressure (BP) increases accompanied by heart rate (HR) decreases. Dose-response and time-response effects were obtained for the HR and BP changes following stimulation under alpha-adrenergic (phentolamine), beta-adrenergic (propranolol) and cholinergic (atropine methylnitrate, atropine sulfate) blocking agents. By examining the relationship of BP and HR changes during stimulation under graded doses of the blocking agents, the HR decreases were shown to be mainly reflex responses to sympathetically-induced BP increases.

AB - Unanesthetized rabbits received high frequency, short pulse-train duration electrical stimulation of septal region and hypothalamic locations at current intensities producing blood pressure (BP) increases accompanied by heart rate (HR) decreases. Dose-response and time-response effects were obtained for the HR and BP changes following stimulation under alpha-adrenergic (phentolamine), beta-adrenergic (propranolol) and cholinergic (atropine methylnitrate, atropine sulfate) blocking agents. By examining the relationship of BP and HR changes during stimulation under graded doses of the blocking agents, the HR decreases were shown to be mainly reflex responses to sympathetically-induced BP increases.

KW - Alpha-adrenergic blockade

KW - Atropine

KW - Beta-adrenergic blockade

KW - Blood pressure

KW - Heart rate

KW - Rabbits

KW - Subcortical electrical stimulation

UR - http://www.scopus.com/inward/record.url?scp=0015345481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015345481&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(72)90306-X

DO - 10.1016/0031-9384(72)90306-X

M3 - Article

VL - 8

SP - 927

EP - 936

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 5

ER -