Adrenergic airway vascular smooth muscle responsiveness in healthy and asthmatic subjects

Jorge Brieva, Adam Wanner

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The purpose of the present study was to determine the responsiveness of airway vascular smooth muscle (AVSM) as assessed by airway mucosal blood flow (Qaw) to inhaled methoxamine (α1-agonist; 0.6-2.3 mg) and albuterol (β2-agonist; 0.2-1.2 mg) in healthy [n = 11; forced expiratory volume in 1 s, 92 ± 4 (SE) % of predicted] and asthmatic (n = 11, mean forced expiratory volume in 1 s, 81 ± 5%) adults. Mean baseline values for Qaw were 43.8 ± 0.7 and 54.3 ± 0.8 μl·min-1·ml-1 of anatomic dead space in healthy and asthmatic subjects, respectively (P < 0.05). After methoxamine inhalation, the maximal mean change in Qaw was -13.5 ± 1.0 μl·min-1·ml-1 in asthmatic and -7.1 ± 2.1 μl·min-1·ml-1 in healthy subjects (P < 0.05). After albuterol, the mean maximal change in Qaw was 3.0 ± 0.8 μl·min-1·ml-1 in asthmatic and 14.0 ± 1.1 μl·min-1·ml-1 in healthy subjects (P < 0.05). These results demonstrate that the contractile response of AVSM to α1-adrenoceptor activation is enhanced and the dilator response of AVSM to β2-adrenoceptor activation is blunted in asthmatic subjects.

Original languageEnglish (US)
Pages (from-to)665-669
Number of pages5
JournalJournal of applied physiology
Volume90
Issue number2
StatePublished - Feb 15 2001

Keywords

  • Adrenergic agonists
  • Asthma
  • Bronchial blood flow

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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