Adrenal medullary grafts suppress c-fos induction in spinal neurons of arthritic rats

Jacqueline Sagen, Hong Wang

Research output: Contribution to journalArticle

23 Scopus citations


Expression of immediate-early genes such as c-fos is thought to reflect patterns of neuronal activity in the central nervous system. Prolonged increases in Fos-protein-like-immunoreactivity (FOS-LI) are seen in the dorsal horn of adjuvant arthritic rats, and parallel increased pain behavior. Grafts of adrenal medullary, but not control tissue, into the spinal subarachnoid space reduce pain behavior and suppress the induction of spinal Fos-LI in arthritic rats. This reduction is particularly marked in superficial laminae (I-II), but is also significant in deeper laminae (III-IV and V-VI). The results of this study suggest that adrenal medullary transplants reduce spinal cord hyperactivation consequent to painful peripheral inflammation.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - Jun 16 1995
Externally publishedYes



  • Chromaffin cells
  • Dorsal horn
  • Immediate-early gene
  • Inflammation
  • Neural transplants
  • Nociception
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)

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