Adrenal Medullary Autografts in Patients with Parkinson's Disease

Shou Shu Jiao, yu ji Ding, wa Cheng Zhang, Jia Kang Cao, Guo Feng Zhang, Zhi Ming Zhang, Ming Chen Ding, Zhu Zhang, Jia Mei Meng, Caroline M. Tanner, Ray L. Watts, Roy A.E. Bakay, Kenneth C. Petruk, Joseph Jankovic, William J. Weiner, Juan Sanchez-Ramos, Carlos Singer, Christopher G. Goetz, C. Warren Olanow, William C. Koller

Research output: Contribution to journalLetter

20 Scopus citations

Abstract

To the Editor: From July 1986 to June 1987, 10 patients with Parkinson's disease were treated by our group in China with stereotaxic implantation of autologous adrenal medullary tissue with a silver carrier into the head of the right caudate nucleus. Subsequent clinical evaluation has shown a long-term anti-parkinsonism effect with no use of dopaminergic medication (Table 1). In eight patients, the preoperative symptom was characterized as “akinetic-rigidity–predominant type,” and in two others as “tremor-predominant type.” All had advanced idiopathic Parkinson's disease, complicated by severe motor fluctuations that could not be controlled adequately with any medication. The patients were monitored.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalNew England Journal of Medicine
Volume321
Issue number5
DOIs
StatePublished - Aug 3 1989

ASJC Scopus subject areas

  • Medicine(all)

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    Jiao, S. S., Ding, Y. J., Zhang, W. C., Cao, J. K., Zhang, G. F., Zhang, Z. M., Ding, M. C., Zhang, Z., Meng, J. M., Tanner, C. M., Watts, R. L., Bakay, R. A. E., Petruk, K. C., Jankovic, J., Weiner, W. J., Sanchez-Ramos, J., Singer, C., Goetz, C. G., Olanow, C. W., & Koller, W. C. (1989). Adrenal Medullary Autografts in Patients with Parkinson's Disease. New England Journal of Medicine, 321(5), 324-327. https://doi.org/10.1056/NEJM198908033210512