Adrenal function in major depression

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The adrenal gland consists of two morphologically and functionally distinct tissues, the medulla and the cortex. There is evidence for sympathoadrenal hyperactivity in many patients with major depression and literally hundreds of reports documenting hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in drug-free depressed patients. This 'endocrinopathy' has been shown to be associated with alterations in the adrenal cortex (glucocorticoid), pituitary (β-endorphin and ACTH), and central nervous system (CRF) of depressed patients. The hyperactivity of the sympathoadrenomedullary system and the HPA axis in major depression is described in detail, including the pathophysiological and treatment implications of these findings.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalEndocrinologist
Volume5
Issue number2
StatePublished - Apr 6 1995
Externally publishedYes

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Pituitary-Adrenal System
Endorphins
Adrenal Cortex
Adrenal Glands
Adrenocorticotropic Hormone
Glucocorticoids
Central Nervous System
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Endocrinology

Cite this

Adrenal function in major depression. / Musselman, Dominique; Nemeroff, Charles.

In: Endocrinologist, Vol. 5, No. 2, 06.04.1995, p. 91-96.

Research output: Contribution to journalArticle

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