Adrenal function in major depression

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Abstract

The adrenal gland consists of two morphologically and functionally distinct tissues, the medulla and the cortex. There is evidence for sympathoadrenal hyperactivity in many patients with major depression and literally hundreds of reports documenting hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in drug-free depressed patients. This 'endocrinopathy' has been shown to be associated with alterations in the adrenal cortex (glucocorticoid), pituitary (β-endorphin and ACTH), and central nervous system (CRF) of depressed patients. The hyperactivity of the sympathoadrenomedullary system and the HPA axis in major depression is described in detail, including the pathophysiological and treatment implications of these findings.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalEndocrinologist
Volume5
Issue number2
DOIs
StatePublished - Mar 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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