Admission Hyperglycemia Predicts Infectious Complications After Burns

Juliet J. Ray, Jonathan P. Meizoso, Casey J. Allen, Laura F. Teisch, Ethan Y. Yang, Han Yao Foong, Leela S. Mundra, Nicholas Namias, Louis R Pizano, Carl I Schulman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Inflammation and hypermetabolism post burn predisposes to hyperglycemia and insulin resistance. The authors hypothesize that admission hyperglycemia predicts infectious outcomes. A retrospective review of all patients greater than 20 years of age admitted for initial burn management from January 2008 to December 2013 was conducted. Nonthermal injuries, transfers, and those without admission glucose or histories were excluded. Hyperglycemia was defined as admission glucose ≥150 mg/dl. Patients were grouped as follows: euglycemic without diabetes (control), euglycemic with diabetes (−H+D), hyperglycemic without diabetes (+H−D), and hyperglycemic with diabetes (+H+D). Outcomes included infection, mortality, length of stay, and disposition. Comparisons were made using Fisher’s exact test and multiple logistic regression. A total of 411 patients were analyzed. No significant differences between any of the groups and controls were noted in race, inhalation injury, or obesity. All three groups had higher mortality compared with controls. Longer hospital stays were noted only in +H−D. +H−D and +H+D were less likely to be discharged home than controls. +H−D had higher rates of bacteremia, +H−D and +H+D had higher rates of pneumonia, and −H+D and +H−D had higher rates of urinary tract infection. Regression for infection and mortality outcomes with TBSA, age, diabetes, hyperglycemia, obesity, race, gender, and inhalation injury as covariates was performed. Hyperglycemia was the only independent predictor of bacteremia (area under curve [AUC] = 0.736). Hyperglycemia was also a predictor of pneumonia and urinary tract infection (AUC = 0.766 and 0.802, respectively). The only independent predictors of mortality were age, TBSA, and inhalation injury (AUC = 0.892). Acute glucose dysregulation may be more important than diabetes in predicting infectious outcomes after burns. Therefore, admission glucose may have prognostic value.

Original languageEnglish (US)
JournalJournal of Burn Care and Research
DOIs
StateAccepted/In press - Jun 27 2016

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Burns
Hyperglycemia
Inhalation
Area Under Curve
Glucose
Mortality
Wounds and Injuries
Bacteremia
Urinary Tract Infections
Length of Stay
Pneumonia
Obesity
Infection
Insulin Resistance
Logistic Models
Inflammation
Control Groups

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

Cite this

Admission Hyperglycemia Predicts Infectious Complications After Burns. / Ray, Juliet J.; Meizoso, Jonathan P.; Allen, Casey J.; Teisch, Laura F.; Yang, Ethan Y.; Foong, Han Yao; Mundra, Leela S.; Namias, Nicholas; Pizano, Louis R; Schulman, Carl I.

In: Journal of Burn Care and Research, 27.06.2016.

Research output: Contribution to journalArticle

Ray, Juliet J. ; Meizoso, Jonathan P. ; Allen, Casey J. ; Teisch, Laura F. ; Yang, Ethan Y. ; Foong, Han Yao ; Mundra, Leela S. ; Namias, Nicholas ; Pizano, Louis R ; Schulman, Carl I. / Admission Hyperglycemia Predicts Infectious Complications After Burns. In: Journal of Burn Care and Research. 2016.
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abstract = "Inflammation and hypermetabolism post burn predisposes to hyperglycemia and insulin resistance. The authors hypothesize that admission hyperglycemia predicts infectious outcomes. A retrospective review of all patients greater than 20 years of age admitted for initial burn management from January 2008 to December 2013 was conducted. Nonthermal injuries, transfers, and those without admission glucose or histories were excluded. Hyperglycemia was defined as admission glucose ≥150 mg/dl. Patients were grouped as follows: euglycemic without diabetes (control), euglycemic with diabetes (−H+D), hyperglycemic without diabetes (+H−D), and hyperglycemic with diabetes (+H+D). Outcomes included infection, mortality, length of stay, and disposition. Comparisons were made using Fisher’s exact test and multiple logistic regression. A total of 411 patients were analyzed. No significant differences between any of the groups and controls were noted in race, inhalation injury, or obesity. All three groups had higher mortality compared with controls. Longer hospital stays were noted only in +H−D. +H−D and +H+D were less likely to be discharged home than controls. +H−D had higher rates of bacteremia, +H−D and +H+D had higher rates of pneumonia, and −H+D and +H−D had higher rates of urinary tract infection. Regression for infection and mortality outcomes with TBSA, age, diabetes, hyperglycemia, obesity, race, gender, and inhalation injury as covariates was performed. Hyperglycemia was the only independent predictor of bacteremia (area under curve [AUC] = 0.736). Hyperglycemia was also a predictor of pneumonia and urinary tract infection (AUC = 0.766 and 0.802, respectively). The only independent predictors of mortality were age, TBSA, and inhalation injury (AUC = 0.892). Acute glucose dysregulation may be more important than diabetes in predicting infectious outcomes after burns. Therefore, admission glucose may have prognostic value.",
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