Administration of oxaliplatin to a pregnant woman with rectal cancer

Michael Gensheimer, Catherine A. Jones, Cornelia R. Graves, Nipun B. Merchant, A. Craig Lockhart

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Purpose The platinum agent oxaliplatin could be useful in treatment of cancer in pregnant women, but it is fetotoxic in rats and its effect on the human fetus is unknown. Oxaliplatin was administered to a 25-year-old pregnant woman with metastatic rectal cancer from 20 to 30 weeks gestational age as part of the mFOLFOX-6 regimen. Results The patient gave birth to a healthy girl at 33 weeks gestational age. At follow-up, the 3-year-old child had achieved all appropriate growth and developmental milestones. Discussion Oxaliplatin is a component of several modern chemotherapy regimens. This report demonstrates the administration of oxaliplatin in the second and third trimesters of pregnancy without apparent fetal harm.

Original languageEnglish (US)
Pages (from-to)371-373
Number of pages3
JournalCancer Chemotherapy And Pharmacology
Volume63
Issue number2
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Colorectal cancer
  • Oxaliplatin
  • Pregnancy

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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