Administration of LH-releasing hormone to selected subjects

Abba J. Kastin, Andrew V. Schally, Carlos Gual, A. Rees Midgley, Cyril Y. Bowers, F. Gomez-Perez

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Administration of highly purified porcine LH-releasing hormone (LRH) to 12 human beings caused a maximum mean increase in serum LH of 460 per cent. Lysine vasopressin, used as a control substance, had almost (10 per cent) no effect. The selected subjects were divided into several groups, so that specific aspects of the effects of LRH could be studied. Postmenopausal women were responsive to LRH regardless of whether or not their serum LH levels had been supressed by pretreatment with an oral contraceptive. Subcutaneous administration of LRH was at least as effective as the intravenous route of administration. Putrescine did not elevate serum FSH or LH levels and did not augment the response to LRH. This study demonstrates the effectiveness of LRH of porcine origin in releasing LH in the human being.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume108
Issue number2
DOIs
StatePublished - Sep 15 1970
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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