ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

Robert Yarchoan, KentJ Weinhold, H. Kim Lyerly, Edward Gelmann, RobertM Blum, GeneM Shearer, Hiroaki Mitsuya, JerryM Collins, CharlesE Myers, RaymondW Klecker, PhillipD Markham, DavidT Durack, S. Nusinoff Lehrman, DavidW Barry, Margaret A Fischl, RobertC Gallo, DaniP Bolognesi, Samuel Broder

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Abstract

In a 6-week clinical trial 4 dose regimens of 3'-azido-3'-deoxythymidine (AZT), a thymidine analogue with potent anti-viral activity against HTLV-III in vitro, were examined in 19 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). AZT was given intravenously for 2 weeks, then orally for 4 weeks at twice the intravenous dose. AZT was well absorbed from the gut and crossed the bloodbrain barrier. Therapeutic levels were maintained with 5 mg given intravenously or 10 mg given orally every 4 h. Treatment was not limited by side-effects, the commonest of which were headaches and depression of white-cell counts. 15 of the 19 patients had increases in their numbers of circulating helper-inducer T lymphocytes (p<0·001) during therapy, 6 who were anergic at entry showed positive delayed type hypersensitivity skin test reactions during treatment, 2 had clearance of chronic fungal nailbed infections without specific anti-fungal therapy, 6 had other evidence of clinical improvement, and the group as a whole had a weight gain of 2·2 kg. Also, with the highest dose regimen cultures of peripheral blood mononuclear cells for HTLV III became negative.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalThe Lancet
Volume327
Issue number8481
DOIs
StatePublished - Mar 15 1986

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yarchoan, R., Weinhold, K., Lyerly, H. K., Gelmann, E., Blum, R., Shearer, G., Mitsuya, H., Collins, J., Myers, C., Klecker, R., Markham, P., Durack, D., Lehrman, S. N., Barry, D., Fischl, M. A., Gallo, R., Bolognesi, D., & Broder, S. (1986). ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX. The Lancet, 327(8481), 575-580. https://doi.org/10.1016/S0140-6736(86)92808-4