Adjuvant whole brain radiation following resection of brain metastases

David F. Slottje, Joon Hyung Kim, Lisa Wang, Daniel M.S. Raper, Ashish H. Shah, Amade Bregy, Michael Furlong, Karthik Madhavan, Brian E Lally, Ricardo J. Komotar

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Brain metastasis is a common complication of systemic cancer and significant cause of suffering in oncology patients. Despite a plethora of available treatment modalities, the prognosis is poor with a median survival time of approximately one year. For patients with controlled systemic disease, good performance status, and a limited number of metastases, treatment typically entails surgical resection or radiosurgery, followed by whole brain radiotherapy (WBRT) to control microscopic disease. WBRT is known to control the progression of cancer in the brain, but it can also have toxic effects, particularly with regard to neurocognition. There is no consensus as to whether the benefit of WBRT outweighs the potential harm. We review the evidence related to the question of whether patients undergoing surgical resection of brain metastases should receive adjuvant WBRT.

Original languageEnglish (US)
Pages (from-to)771-775
Number of pages5
JournalJournal of Clinical Neuroscience
Volume20
Issue number6
DOIs
StatePublished - Jun 2013

Keywords

  • Brain metastases
  • Radiation therapy
  • Whole brain radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

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  • Cite this

    Slottje, D. F., Kim, J. H., Wang, L., Raper, D. M. S., Shah, A. H., Bregy, A., Furlong, M., Madhavan, K., Lally, B. E., & Komotar, R. J. (2013). Adjuvant whole brain radiation following resection of brain metastases. Journal of Clinical Neuroscience, 20(6), 771-775. https://doi.org/10.1016/j.jocn.2012.09.026