Adjuvant whole brain radiation following resection of brain metastases

David F. Slottje, Joon Hyung Kim, Lisa Wang, Daniel M S Raper, Ashish H. Shah, Amade Bregy, Michael Furlong, Karthik Madhavan, Brian E. Lally, Ricardo J Komotar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Brain metastasis is a common complication of systemic cancer and significant cause of suffering in oncology patients. Despite a plethora of available treatment modalities, the prognosis is poor with a median survival time of approximately one year. For patients with controlled systemic disease, good performance status, and a limited number of metastases, treatment typically entails surgical resection or radiosurgery, followed by whole brain radiotherapy (WBRT) to control microscopic disease. WBRT is known to control the progression of cancer in the brain, but it can also have toxic effects, particularly with regard to neurocognition. There is no consensus as to whether the benefit of WBRT outweighs the potential harm. We review the evidence related to the question of whether patients undergoing surgical resection of brain metastases should receive adjuvant WBRT.

Original languageEnglish
Pages (from-to)771-775
Number of pages5
JournalJournal of Clinical Neuroscience
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2013

Fingerprint

Radiation
Neoplasm Metastasis
Brain
Radiotherapy
Radiosurgery
Poisons
Brain Neoplasms
Survival
Therapeutics
Neoplasms

Keywords

  • Brain metastases
  • Radiation therapy
  • Whole brain radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

Cite this

Adjuvant whole brain radiation following resection of brain metastases. / Slottje, David F.; Kim, Joon Hyung; Wang, Lisa; Raper, Daniel M S; Shah, Ashish H.; Bregy, Amade; Furlong, Michael; Madhavan, Karthik; Lally, Brian E.; Komotar, Ricardo J.

In: Journal of Clinical Neuroscience, Vol. 20, No. 6, 01.06.2013, p. 771-775.

Research output: Contribution to journalArticle

Slottje, DF, Kim, JH, Wang, L, Raper, DMS, Shah, AH, Bregy, A, Furlong, M, Madhavan, K, Lally, BE & Komotar, RJ 2013, 'Adjuvant whole brain radiation following resection of brain metastases', Journal of Clinical Neuroscience, vol. 20, no. 6, pp. 771-775. https://doi.org/10.1016/j.jocn.2012.09.026
Slottje, David F. ; Kim, Joon Hyung ; Wang, Lisa ; Raper, Daniel M S ; Shah, Ashish H. ; Bregy, Amade ; Furlong, Michael ; Madhavan, Karthik ; Lally, Brian E. ; Komotar, Ricardo J. / Adjuvant whole brain radiation following resection of brain metastases. In: Journal of Clinical Neuroscience. 2013 ; Vol. 20, No. 6. pp. 771-775.
@article{25830c4d55604b6da003741ea66a6ba7,
title = "Adjuvant whole brain radiation following resection of brain metastases",
abstract = "Brain metastasis is a common complication of systemic cancer and significant cause of suffering in oncology patients. Despite a plethora of available treatment modalities, the prognosis is poor with a median survival time of approximately one year. For patients with controlled systemic disease, good performance status, and a limited number of metastases, treatment typically entails surgical resection or radiosurgery, followed by whole brain radiotherapy (WBRT) to control microscopic disease. WBRT is known to control the progression of cancer in the brain, but it can also have toxic effects, particularly with regard to neurocognition. There is no consensus as to whether the benefit of WBRT outweighs the potential harm. We review the evidence related to the question of whether patients undergoing surgical resection of brain metastases should receive adjuvant WBRT.",
keywords = "Brain metastases, Radiation therapy, Whole brain radiotherapy",
author = "Slottje, {David F.} and Kim, {Joon Hyung} and Lisa Wang and Raper, {Daniel M S} and Shah, {Ashish H.} and Amade Bregy and Michael Furlong and Karthik Madhavan and Lally, {Brian E.} and Komotar, {Ricardo J}",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.jocn.2012.09.026",
language = "English",
volume = "20",
pages = "771--775",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",
number = "6",

}

TY - JOUR

T1 - Adjuvant whole brain radiation following resection of brain metastases

AU - Slottje, David F.

AU - Kim, Joon Hyung

AU - Wang, Lisa

AU - Raper, Daniel M S

AU - Shah, Ashish H.

AU - Bregy, Amade

AU - Furlong, Michael

AU - Madhavan, Karthik

AU - Lally, Brian E.

AU - Komotar, Ricardo J

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Brain metastasis is a common complication of systemic cancer and significant cause of suffering in oncology patients. Despite a plethora of available treatment modalities, the prognosis is poor with a median survival time of approximately one year. For patients with controlled systemic disease, good performance status, and a limited number of metastases, treatment typically entails surgical resection or radiosurgery, followed by whole brain radiotherapy (WBRT) to control microscopic disease. WBRT is known to control the progression of cancer in the brain, but it can also have toxic effects, particularly with regard to neurocognition. There is no consensus as to whether the benefit of WBRT outweighs the potential harm. We review the evidence related to the question of whether patients undergoing surgical resection of brain metastases should receive adjuvant WBRT.

AB - Brain metastasis is a common complication of systemic cancer and significant cause of suffering in oncology patients. Despite a plethora of available treatment modalities, the prognosis is poor with a median survival time of approximately one year. For patients with controlled systemic disease, good performance status, and a limited number of metastases, treatment typically entails surgical resection or radiosurgery, followed by whole brain radiotherapy (WBRT) to control microscopic disease. WBRT is known to control the progression of cancer in the brain, but it can also have toxic effects, particularly with regard to neurocognition. There is no consensus as to whether the benefit of WBRT outweighs the potential harm. We review the evidence related to the question of whether patients undergoing surgical resection of brain metastases should receive adjuvant WBRT.

KW - Brain metastases

KW - Radiation therapy

KW - Whole brain radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84891873196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891873196&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2012.09.026

DO - 10.1016/j.jocn.2012.09.026

M3 - Article

C2 - 23632290

AN - SCOPUS:84891873196

VL - 20

SP - 771

EP - 775

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

IS - 6

ER -