Adjuvant Therapies in Metastatic Bone Disease

Raphael Yechieli, Steven Bialick, Crystal Seldon, Emily Jonczak

Research output: Contribution to journalArticlepeer-review


Bone is a common site of metastatic disease in both solid tumor and hematologic malignancies. Skeletal involvement of cancer and the complications from these metastases can produce significant morbidity including, but not limited to, pathologic fractures and pain, hypercalcemia, and spinal cord or nerve root compression with neurologic compromise. Modern therapeutic advances have been developed towards the preservation of independence and improvement in quality of life, specifically with loss of mobility and social functioning in patients with metastatic bone disease. As such, the management of bone metastases is often complex, requiring an interdisciplinary and multimodal approach among surgeons, radiation oncologists, and medical oncologists. The aim of this discussion is to highlight the current recommendations regarding adjuvant treatments – local and systemic – in metastatic bone disease, including both radiotherapy and pharmaceutical interventions.

Original languageEnglish (US)
Article number100899
JournalOperative Techniques in Orthopaedics
Issue number3
StatePublished - Sep 2021
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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