Adjuvant chemotherapy with carmustine and cisplatin for patients with malignant gliomas

W. K.Alfred Yung, Todd J. Janus, Moshe Maor, Lynn G. Feun

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Forty-five patients with malignant gliomas were treated after aggressive surgical resection with alternating intravenous carmustine and cisplatin both during and after radiation therapy. Thirty-three patients were considered evaluable for responses, 17 had glioblastoma multiforme (GBM),14 had anaplastic astrocytoma (AA) and 2 had anaplastic oligodendroglioma (AO). The median age of the evaluable patients was 47 years. The median time to tumor progression was 34.5 weeks, and the median survival for the entire group was 76 weeks. Early progression occurred more frequently in patients with glioblastoma than in those with AA or AO. Seventeen patients (55%) were alive at 18 months (6 GBM, 9 AA, 2 AO). Toxicity was mainly hematologic, otic and tolerable. The results suggest that further trial is warranted to assess the efficacy of alternating carmustine and cisplatin in conjunction with radiation therapy postoperatively in patients with malignant gliomas.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalJournal of neuro-oncology
Volume12
Issue number2
DOIs
StatePublished - Feb 1 1992
Externally publishedYes

Keywords

  • carmustine
  • chemotherapy
  • cisplatin
  • malignant gliomas

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

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