Adjunctive use of transconjunctival mitomycin-C in Ab externo diode laser sclerostomy surgery in rabbits

C. L. Karp, E. J. Higginbotham, E. O. Griffin

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

This study evaluates the role of transconjunctival mitomycin-C (MMC) in laser sclerostomy surgery. Sixteen albino rabbits underwent ab externo diode laser sclerostomy surgery in one eye (with the fellow eye as a control), with a single, intraoperative, 7-minute transconjunctival application of MMC (MMC group). Ten rabbits had the same sclerostomy surgery without MMC (NOMMC group). Successful filtration, defined as a difference in intraocular pressure less than 4 mm Hg between the operative and control eyes, lasted significantly longer in the MMC group (16.4 ± 11.0 days) than in the NOMMC group (8.5 ± 4.5 days) (P = .02). These data suggest that transconjunctival MMC can enhance the success of diode laser sclerostomy surgery in rabbits.

Original languageEnglish (US)
Pages (from-to)23-27
Number of pages5
JournalOphthalmic surgery
Volume25
Issue number1
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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