Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women

A. S. Ryan, B. J. Nicklas, D. M. Berman, D. Elahi

Research output: Contribution to journalArticlepeer-review

157 Scopus citations


OBJECTIVE: The purpose of this study was to determine changes in adiponectin levels with moderate weight loss, weight loss plus aerobic exercise, or weight loss plus resistive exercise in overweight and obese, sedentary postmenopausal women. DESIGN: Longitudinal, clinical intervention study of 6-month (3 x /week) program of either weight loss (WL, n = 1 5), weight loss + aerobic exercise (WL+AEX, n = 16), or weight loss + resistive exercise (WL+RT, n = 9) SUBJECTS: We studied 40 sedentary, overweight and obese (body mass index, BMI = 32 ± 1 kg/m2, X ± s.e.m.) postmenopausal (57 ± 1y) women. MEASUREMENTS: Fat mass and fat-free mass (FFM) by dual-energy X-ray absorptiometry, plasma insulin, leptin, and adiponectin by radioimmunoassay. RESULTS: Age, body weight, BMI, waist and hip circumferences, waist-to-hip ratio, VO2max, percent fat, total body fat mass, FFM, and fasting plasma glucose, insulin, leptin, and adiponectin concentrations were similar among WL, WL+AEX, and WL+RT groups before the interventions. In all women combined, body weight, BMI, and waist and hip circumferences decreased (P < 0.001). There was a significant absolute decrease in percent body fat from 47 to 44%, representing a 13% decrease in total fat mass and a -1.6% change in FFM. Fasting concentrations of plasma adiponectin did not change (40 ± 16%, P = NS), whereas fasting plasma glucose, insulin, and leptin all decreased (P < 0.001). CONCLUSIONS: Plasma adiponectin levels do not change with a 6-month moderate weight reduction program even when accompanied by aerobic or resistive exercise training in overweight and obese postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1066-1071
Number of pages6
JournalInternational Journal of Obesity
Issue number9
StatePublished - Sep 1 2003
Externally publishedYes


  • Adiponectin
  • Adipose tissue
  • Leptin
  • Physical activity
  • Weight reduction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism


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