Abstract
Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were enrolled for the study. We selected 16 patients who underwent elective coronary artery bypass graft surgery for critical CAD, 5 who underwent surgery for valve replacement and 1 for correction of an interatrial defect. Epicardial adipose tissue biopsy samples were obtained before the initiation of cardiopulmonary bypass. Adiponectin protein level in epicardial adipose tissue was evaluated by Western blotting. Results: Adiponectin protein value, expressed as adiponectin/actin ratio, in epicardial adipose tissue was significantly lower in patients with severe CAD than in those without CAD (1.42 ± 0.77 vs 2.36 ± 0.84 p = 0.02, 95% CI 0.64-1.74). Conclusions: This study showed for the first time that human epicardial adipose tissue expresses adiponectin. Adiponectin expression is significantly lower in epicardial fat isolated from patients with CAD.
| Original language | English |
|---|---|
| Pages (from-to) | 251-255 |
| Number of pages | 5 |
| Journal | Cytokine |
| Volume | 29 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 21 2005 |
| Externally published | Yes |
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Keywords
- Adiponectin
- Coronary artery disease
- Epicardial adipose tissue
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Immunology
- Immunology and Allergy
Cite this
Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. / Iacobellis, Gianluca; Pistilli, Daniela; Gucciardo, Marco; Leonetti, Frida; Miraldi, Fabio; Brancaccio, Gianluca; Gallo, Pietro; Tiziana Di Gioia, Cira Rosaria.
In: Cytokine, Vol. 29, No. 6, 21.03.2005, p. 251-255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease
AU - Iacobellis, Gianluca
AU - Pistilli, Daniela
AU - Gucciardo, Marco
AU - Leonetti, Frida
AU - Miraldi, Fabio
AU - Brancaccio, Gianluca
AU - Gallo, Pietro
AU - Tiziana Di Gioia, Cira Rosaria
PY - 2005/3/21
Y1 - 2005/3/21
N2 - Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were enrolled for the study. We selected 16 patients who underwent elective coronary artery bypass graft surgery for critical CAD, 5 who underwent surgery for valve replacement and 1 for correction of an interatrial defect. Epicardial adipose tissue biopsy samples were obtained before the initiation of cardiopulmonary bypass. Adiponectin protein level in epicardial adipose tissue was evaluated by Western blotting. Results: Adiponectin protein value, expressed as adiponectin/actin ratio, in epicardial adipose tissue was significantly lower in patients with severe CAD than in those without CAD (1.42 ± 0.77 vs 2.36 ± 0.84 p = 0.02, 95% CI 0.64-1.74). Conclusions: This study showed for the first time that human epicardial adipose tissue expresses adiponectin. Adiponectin expression is significantly lower in epicardial fat isolated from patients with CAD.
AB - Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were enrolled for the study. We selected 16 patients who underwent elective coronary artery bypass graft surgery for critical CAD, 5 who underwent surgery for valve replacement and 1 for correction of an interatrial defect. Epicardial adipose tissue biopsy samples were obtained before the initiation of cardiopulmonary bypass. Adiponectin protein level in epicardial adipose tissue was evaluated by Western blotting. Results: Adiponectin protein value, expressed as adiponectin/actin ratio, in epicardial adipose tissue was significantly lower in patients with severe CAD than in those without CAD (1.42 ± 0.77 vs 2.36 ± 0.84 p = 0.02, 95% CI 0.64-1.74). Conclusions: This study showed for the first time that human epicardial adipose tissue expresses adiponectin. Adiponectin expression is significantly lower in epicardial fat isolated from patients with CAD.
KW - Adiponectin
KW - Coronary artery disease
KW - Epicardial adipose tissue
UR - http://www.scopus.com/inward/record.url?scp=14644431030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14644431030&partnerID=8YFLogxK
U2 - 10.1016/j.cyto.2004.11.002
DO - 10.1016/j.cyto.2004.11.002
M3 - Article
C2 - 15749025
AN - SCOPUS:14644431030
VL - 29
SP - 251
EP - 255
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 6
ER -