Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease

Gianluca Iacobellis, Daniela Pistilli, Marco Gucciardo, Frida Leonetti, Fabio Miraldi, Gianluca Brancaccio, Pietro Gallo, Cira Rosaria Tiziana Di Gioia

Research output: Contribution to journalArticle

307 Citations (Scopus)

Abstract

Background: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic syndrome and may contribute to the risk for cardiovascular disease by the production of adipocytokines, including adiponectin. Nevertheless, there is no knowledge on whether other visceral depots of adipose tissue, including the epicardial fat, have any metabolically active role, including production of adiponectin. Aim of the study: We sought to evaluate adiponectin protein expression in epicardial adipose tissue in vivo both in patients with severe coronary artery disease (CAD) and in subjects without CAD. Methods: Twenty-two patients were enrolled for the study. We selected 16 patients who underwent elective coronary artery bypass graft surgery for critical CAD, 5 who underwent surgery for valve replacement and 1 for correction of an interatrial defect. Epicardial adipose tissue biopsy samples were obtained before the initiation of cardiopulmonary bypass. Adiponectin protein level in epicardial adipose tissue was evaluated by Western blotting. Results: Adiponectin protein value, expressed as adiponectin/actin ratio, in epicardial adipose tissue was significantly lower in patients with severe CAD than in those without CAD (1.42 ± 0.77 vs 2.36 ± 0.84 p = 0.02, 95% CI 0.64-1.74). Conclusions: This study showed for the first time that human epicardial adipose tissue expresses adiponectin. Adiponectin expression is significantly lower in epicardial fat isolated from patients with CAD.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalCytokine
Volume29
Issue number6
DOIs
StatePublished - Mar 21 2005
Externally publishedYes

Fingerprint

Adiponectin
Adipose Tissue
Coronary Artery Disease
Tissue
Surgery
Fats
Proteins
Adipokines
Intra-Abdominal Fat
Biopsy
Cardiopulmonary Bypass
Grafts
Coronary Artery Bypass
Actins
Cardiovascular Diseases
Western Blotting
Transplants
Defects

Keywords

  • Adiponectin
  • Coronary artery disease
  • Epicardial adipose tissue

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Iacobellis, G., Pistilli, D., Gucciardo, M., Leonetti, F., Miraldi, F., Brancaccio, G., ... Tiziana Di Gioia, C. R. (2005). Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine, 29(6), 251-255. https://doi.org/10.1016/j.cyto.2004.11.002

Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. / Iacobellis, Gianluca; Pistilli, Daniela; Gucciardo, Marco; Leonetti, Frida; Miraldi, Fabio; Brancaccio, Gianluca; Gallo, Pietro; Tiziana Di Gioia, Cira Rosaria.

In: Cytokine, Vol. 29, No. 6, 21.03.2005, p. 251-255.

Research output: Contribution to journalArticle

Iacobellis, G, Pistilli, D, Gucciardo, M, Leonetti, F, Miraldi, F, Brancaccio, G, Gallo, P & Tiziana Di Gioia, CR 2005, 'Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease', Cytokine, vol. 29, no. 6, pp. 251-255. https://doi.org/10.1016/j.cyto.2004.11.002
Iacobellis, Gianluca ; Pistilli, Daniela ; Gucciardo, Marco ; Leonetti, Frida ; Miraldi, Fabio ; Brancaccio, Gianluca ; Gallo, Pietro ; Tiziana Di Gioia, Cira Rosaria. / Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. In: Cytokine. 2005 ; Vol. 29, No. 6. pp. 251-255.
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