Adherence to early antiretroviral therapy: Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples

Steven Safren, Kenneth H. Mayer, San San Ou, Marybeth McCauley, Beatriz Grinsztejn, Mina C. Hosseinipour, Nagalingeswaran Kumarasamy, Theresa Gamble, Irving Hoffman, David Celentano, Ying Qing Chen, Myron S. Cohen

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Combination antiretroviral therapy (ART) for HIV-1-infected individuals prevents sexual transmission if viral load is suppressed. Methods: Participants were HIV-1-infected partners randomized to early ART (CD4 350-550) in HPTN052 (n 886, median follow-up 2.1 years), a clinical trial of early ART to prevent sexual transmission of HIV-1 in serodiscordant couples at 13 sites in 9 countries. Adherence was assessed through pill count (dichotomized at

Original languageEnglish (US)
Pages (from-to)234-240
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume69
Issue number2
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

Fingerprint

Secondary Prevention
HIV-1
Viral Load
Therapeutics
Clinical Trials

Keywords

  • adherence
  • ART for prevention
  • treatment as prevention

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Adherence to early antiretroviral therapy : Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples. / Safren, Steven; Mayer, Kenneth H.; Ou, San San; McCauley, Marybeth; Grinsztejn, Beatriz; Hosseinipour, Mina C.; Kumarasamy, Nagalingeswaran; Gamble, Theresa; Hoffman, Irving; Celentano, David; Chen, Ying Qing; Cohen, Myron S.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 69, No. 2, 01.06.2015, p. 234-240.

Research output: Contribution to journalArticle

Safren, Steven ; Mayer, Kenneth H. ; Ou, San San ; McCauley, Marybeth ; Grinsztejn, Beatriz ; Hosseinipour, Mina C. ; Kumarasamy, Nagalingeswaran ; Gamble, Theresa ; Hoffman, Irving ; Celentano, David ; Chen, Ying Qing ; Cohen, Myron S. / Adherence to early antiretroviral therapy : Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples. In: Journal of Acquired Immune Deficiency Syndromes. 2015 ; Vol. 69, No. 2. pp. 234-240.
@article{5454b0e5a7294661b6bd0fc654162515,
title = "Adherence to early antiretroviral therapy: Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples",
abstract = "Background: Combination antiretroviral therapy (ART) for HIV-1-infected individuals prevents sexual transmission if viral load is suppressed. Methods: Participants were HIV-1-infected partners randomized to early ART (CD4 350-550) in HPTN052 (n 886, median follow-up 2.1 years), a clinical trial of early ART to prevent sexual transmission of HIV-1 in serodiscordant couples at 13 sites in 9 countries. Adherence was assessed through pill count (dichotomized at",
keywords = "adherence, ART for prevention, treatment as prevention",
author = "Steven Safren and Mayer, {Kenneth H.} and Ou, {San San} and Marybeth McCauley and Beatriz Grinsztejn and Hosseinipour, {Mina C.} and Nagalingeswaran Kumarasamy and Theresa Gamble and Irving Hoffman and David Celentano and Chen, {Ying Qing} and Cohen, {Myron S.}",
year = "2015",
month = "6",
day = "1",
doi = "10.1097/QAI.0000000000000593",
language = "English (US)",
volume = "69",
pages = "234--240",
journal = "Journal of acquired immune deficiency syndromes (1999)",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "2",

}

TY - JOUR

T1 - Adherence to early antiretroviral therapy

T2 - Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples

AU - Safren, Steven

AU - Mayer, Kenneth H.

AU - Ou, San San

AU - McCauley, Marybeth

AU - Grinsztejn, Beatriz

AU - Hosseinipour, Mina C.

AU - Kumarasamy, Nagalingeswaran

AU - Gamble, Theresa

AU - Hoffman, Irving

AU - Celentano, David

AU - Chen, Ying Qing

AU - Cohen, Myron S.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Background: Combination antiretroviral therapy (ART) for HIV-1-infected individuals prevents sexual transmission if viral load is suppressed. Methods: Participants were HIV-1-infected partners randomized to early ART (CD4 350-550) in HPTN052 (n 886, median follow-up 2.1 years), a clinical trial of early ART to prevent sexual transmission of HIV-1 in serodiscordant couples at 13 sites in 9 countries. Adherence was assessed through pill count (dichotomized at

AB - Background: Combination antiretroviral therapy (ART) for HIV-1-infected individuals prevents sexual transmission if viral load is suppressed. Methods: Participants were HIV-1-infected partners randomized to early ART (CD4 350-550) in HPTN052 (n 886, median follow-up 2.1 years), a clinical trial of early ART to prevent sexual transmission of HIV-1 in serodiscordant couples at 13 sites in 9 countries. Adherence was assessed through pill count (dichotomized at

KW - adherence

KW - ART for prevention

KW - treatment as prevention

UR - http://www.scopus.com/inward/record.url?scp=84929920621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929920621&partnerID=8YFLogxK

U2 - 10.1097/QAI.0000000000000593

DO - 10.1097/QAI.0000000000000593

M3 - Article

C2 - 26009832

AN - SCOPUS:84929920621

VL - 69

SP - 234

EP - 240

JO - Journal of acquired immune deficiency syndromes (1999)

JF - Journal of acquired immune deficiency syndromes (1999)

SN - 1525-4135

IS - 2

ER -