Adenovirus infection in pediatric liver and intestinal transplant recipients: Utility of DNA detection by PCR

Gwenn E. McLaughlin, Spiros Delis, Lutifat Kashimawo, G. Patricia Cantwell, Naveen Mittal, Robert E. Cirocco, Phillip Ruiz, Tomoaki Kato, Andreas G. Tzakis

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

To evaluate the incidence of adenovirus (AdV) infection in pediatric liver and intestinal transplant recipients, the records of patients with possible AdV infection were reviewed for demographic data, symptomatology, methods of diagnosis, treatment and outcome. To evaluate the impact of polymerase chain reaction (PCR) amplification and identification of AdV DNA as a diagnostic test, the incidence and outcome of AdV before and after the introduction of PCR were compared. Adenovirus infection was identified in 4.1% of liver recipients and 20.8% of intestinal transplant recipients. The overall incidence of AdV did not increase over time, even following the introduction of PCR for virus detection. The higher incidence of AdV in the pediatric intestinal transplant recipients may be attributed to the frequent application of PCR methodology to intestinal biopsy material. Detection of AdV by PCR was associated with reduced mortality compared with detection by culture, either because of earlier detection of invasive disease or because PCR detects the presence of latent as well as active AdV.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalAmerican Journal of Transplantation
Volume3
Issue number2
DOIs
StatePublished - Feb 2003

Keywords

  • Abdominal transplants
  • Adenovirus
  • Pediatric
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Immunology

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