Adenovirus epithelial keratitis

J. Chodosh, Darlene Miller, W. G. Stroop, S. C. Pflugfelder

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The authors sought to determine whether adenovirus could infect human corneal epithelium in vivo. They reviewed the medical records of six patients with adenovirus-positive vital corneal cultures who were examined at the Bascom Palmer Eye Institute between March 21, 1986, and December 31, 1992. The six patients with adenovirus-positive vital corneal cultures included one patient with dendritic epithelial keratitis, one with geographic epithelial ulceration, three with both geographic ulceration and contiguous dendrites, and one with heaped-up corneal epithelium but no ulceration. Four patients had rose bengal solution applied to their ocular surface, and in all four patients rose bengal uptake was seen at the epithelial edges of the dendrite or geographic ulceration in a manner characteristic of herpes simplex viral keratitis. Serotype determination of the isolates showed adenovirus type 3 (one patient), type 8 (three patients), type 19 (one patient), and indeterminate (one patient). Results of monoclonal antibody staining of cultures against herpes simplex virus (types 1 and 2) antigens was negative for all six cases. Adenovirus epithelial keratitis may result from infection of human corneal epithelium by the virus and rarely may mimic infection of corneal epithelium by herpes simplex virus.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalCornea
Volume14
Issue number2
StatePublished - Jan 1 1995
Externally publishedYes

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Keratitis
Adenoviridae
Corneal Epithelium
Rose Bengal
Dendrites
Dendritic Keratitis
Herpetic Keratitis
Human Herpesvirus 2
Human Herpesvirus 1
Simplexvirus
Infection
Medical Records
Monoclonal Antibodies
Staining and Labeling
Viruses
Antigens

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chodosh, J., Miller, D., Stroop, W. G., & Pflugfelder, S. C. (1995). Adenovirus epithelial keratitis. Cornea, 14(2), 167-174.

Adenovirus epithelial keratitis. / Chodosh, J.; Miller, Darlene; Stroop, W. G.; Pflugfelder, S. C.

In: Cornea, Vol. 14, No. 2, 01.01.1995, p. 167-174.

Research output: Contribution to journalArticle

Chodosh, J, Miller, D, Stroop, WG & Pflugfelder, SC 1995, 'Adenovirus epithelial keratitis', Cornea, vol. 14, no. 2, pp. 167-174.
Chodosh J, Miller D, Stroop WG, Pflugfelder SC. Adenovirus epithelial keratitis. Cornea. 1995 Jan 1;14(2):167-174.
Chodosh, J. ; Miller, Darlene ; Stroop, W. G. ; Pflugfelder, S. C. / Adenovirus epithelial keratitis. In: Cornea. 1995 ; Vol. 14, No. 2. pp. 167-174.
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