Adenosquamous carcinoma of the cervix

Prognosis in early stage disease treated by radical hysterectomy

T. A. Harrison, B. U. Sevin, O. Koechli, H. N. Nguyen, H. E. Averette, M. Penalver, D. M. Donato, Mehrdad Nadji

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The prognosis of adenosquamous carcinoma of the cervix compared to the pure cell types of this disease is a controversial issue. Survival rates vary widely among published series, with some authors finding the prognosis to be much worse and others finding it to be equal. We have studied a group of 290 patients, all of whom had the diagnosis of stage IB or IIA cervical cancer, and all of whom were treated by radical hysterectomy and bilateral pelvic and paraaortic lymphadenectomy. The pathology specimens were reviewed for every case. Median follow-up for all living patients was 73 months. Forty-five patients (15.5%) had adenosquamous histology, 220 (75.9%) had squamous cell, and 25 (8.6%) had adenocarcinoma. By χ2, there was no significant difference among the three groups with regard to race, economic status, number of grade 3 lesions, number with positive pelvic lymph nodes, number with positive margins, stage distribution (IB vs IIA), or number of recurrences. Using Student's t test, there was no significant difference between any combination of two groups with regard to mean patient age, mean depth of invasion, or mean tumor size. Estimated disease-free survival and overall survival were not different among the three cell types. We conclude that for early stage cervical cancer treated by radical hysterectomy, the adenosquamous cell type does not carry a worse prognosis than either of the pure cell types.

Original languageEnglish
Pages (from-to)310-315
Number of pages6
JournalGynecologic Oncology
Volume50
Issue number3
DOIs
StatePublished - Jan 1 1993

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Adenosquamous Carcinoma
Hysterectomy
Cervix Uteri
Uterine Cervical Neoplasms
Lymph Node Excision
Disease-Free Survival
Histology
Adenocarcinoma
Survival Rate
Lymph Nodes
Epithelial Cells
Economics
Pathology
Students
Recurrence
Survival
Neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Adenosquamous carcinoma of the cervix : Prognosis in early stage disease treated by radical hysterectomy. / Harrison, T. A.; Sevin, B. U.; Koechli, O.; Nguyen, H. N.; Averette, H. E.; Penalver, M.; Donato, D. M.; Nadji, Mehrdad.

In: Gynecologic Oncology, Vol. 50, No. 3, 01.01.1993, p. 310-315.

Research output: Contribution to journalArticle

Harrison, TA, Sevin, BU, Koechli, O, Nguyen, HN, Averette, HE, Penalver, M, Donato, DM & Nadji, M 1993, 'Adenosquamous carcinoma of the cervix: Prognosis in early stage disease treated by radical hysterectomy', Gynecologic Oncology, vol. 50, no. 3, pp. 310-315. https://doi.org/10.1006/gyno.1993.1217
Harrison, T. A. ; Sevin, B. U. ; Koechli, O. ; Nguyen, H. N. ; Averette, H. E. ; Penalver, M. ; Donato, D. M. ; Nadji, Mehrdad. / Adenosquamous carcinoma of the cervix : Prognosis in early stage disease treated by radical hysterectomy. In: Gynecologic Oncology. 1993 ; Vol. 50, No. 3. pp. 310-315.
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