Abstract
The prognosis of adenosquamous carcinoma of the cervix compared to the pure cell types of this disease is a controversial issue. Survival rates vary widely among published series, with some authors finding the prognosis to be much worse and others finding it to be equal. We have studied a group of 290 patients, all of whom had the diagnosis of stage IB or IIA cervical cancer, and all of whom were treated by radical hysterectomy and bilateral pelvic and paraaortic lymphadenectomy. The pathology specimens were reviewed for every case. Median follow-up for all living patients was 73 months. Forty-five patients (15.5%) had adenosquamous histology, 220 (75.9%) had squamous cell, and 25 (8.6%) had adenocarcinoma. By χ2, there was no significant difference among the three groups with regard to race, economic status, number of grade 3 lesions, number with positive pelvic lymph nodes, number with positive margins, stage distribution (IB vs IIA), or number of recurrences. Using Student's t test, there was no significant difference between any combination of two groups with regard to mean patient age, mean depth of invasion, or mean tumor size. Estimated disease-free survival and overall survival were not different among the three cell types. We conclude that for early stage cervical cancer treated by radical hysterectomy, the adenosquamous cell type does not carry a worse prognosis than either of the pure cell types.
| Original language | English |
|---|---|
| Pages (from-to) | 310-315 |
| Number of pages | 6 |
| Journal | Gynecologic Oncology |
| Volume | 50 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1993 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
- Oncology
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Adenosquamous carcinoma of the cervix : Prognosis in early stage disease treated by radical hysterectomy. / Harrison, T. A.; Sevin, B. U.; Koechli, O.; Nguyen, H. N.; Averette, H. E.; Penalver, M.; Donato, D. M.; Nadji, Mehrdad.
In: Gynecologic Oncology, Vol. 50, No. 3, 01.01.1993, p. 310-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adenosquamous carcinoma of the cervix
T2 - Prognosis in early stage disease treated by radical hysterectomy
AU - Harrison, T. A.
AU - Sevin, B. U.
AU - Koechli, O.
AU - Nguyen, H. N.
AU - Averette, H. E.
AU - Penalver, M.
AU - Donato, D. M.
AU - Nadji, Mehrdad
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The prognosis of adenosquamous carcinoma of the cervix compared to the pure cell types of this disease is a controversial issue. Survival rates vary widely among published series, with some authors finding the prognosis to be much worse and others finding it to be equal. We have studied a group of 290 patients, all of whom had the diagnosis of stage IB or IIA cervical cancer, and all of whom were treated by radical hysterectomy and bilateral pelvic and paraaortic lymphadenectomy. The pathology specimens were reviewed for every case. Median follow-up for all living patients was 73 months. Forty-five patients (15.5%) had adenosquamous histology, 220 (75.9%) had squamous cell, and 25 (8.6%) had adenocarcinoma. By χ2, there was no significant difference among the three groups with regard to race, economic status, number of grade 3 lesions, number with positive pelvic lymph nodes, number with positive margins, stage distribution (IB vs IIA), or number of recurrences. Using Student's t test, there was no significant difference between any combination of two groups with regard to mean patient age, mean depth of invasion, or mean tumor size. Estimated disease-free survival and overall survival were not different among the three cell types. We conclude that for early stage cervical cancer treated by radical hysterectomy, the adenosquamous cell type does not carry a worse prognosis than either of the pure cell types.
AB - The prognosis of adenosquamous carcinoma of the cervix compared to the pure cell types of this disease is a controversial issue. Survival rates vary widely among published series, with some authors finding the prognosis to be much worse and others finding it to be equal. We have studied a group of 290 patients, all of whom had the diagnosis of stage IB or IIA cervical cancer, and all of whom were treated by radical hysterectomy and bilateral pelvic and paraaortic lymphadenectomy. The pathology specimens were reviewed for every case. Median follow-up for all living patients was 73 months. Forty-five patients (15.5%) had adenosquamous histology, 220 (75.9%) had squamous cell, and 25 (8.6%) had adenocarcinoma. By χ2, there was no significant difference among the three groups with regard to race, economic status, number of grade 3 lesions, number with positive pelvic lymph nodes, number with positive margins, stage distribution (IB vs IIA), or number of recurrences. Using Student's t test, there was no significant difference between any combination of two groups with regard to mean patient age, mean depth of invasion, or mean tumor size. Estimated disease-free survival and overall survival were not different among the three cell types. We conclude that for early stage cervical cancer treated by radical hysterectomy, the adenosquamous cell type does not carry a worse prognosis than either of the pure cell types.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027433487&partnerID=8YFLogxK
U2 - 10.1006/gyno.1993.1217
DO - 10.1006/gyno.1993.1217
M3 - Article
VL - 50
SP - 310
EP - 315
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 3
ER -