Abstract
An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 81-83 |
| Number of pages | 3 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 195 Pt A |
| State | Published - Jan 1 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Adenosine deaminase deficiency and chondro-osseous dysplasia. / Wortmann, R. L.; Veum, J. A.; Cheung, Herman S.
In: Advances in Experimental Medicine and Biology, Vol. 195 Pt A, 01.01.1986, p. 81-83.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adenosine deaminase deficiency and chondro-osseous dysplasia.
AU - Wortmann, R. L.
AU - Veum, J. A.
AU - Cheung, Herman S
PY - 1986/1/1
Y1 - 1986/1/1
N2 - An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.
AB - An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022530045&partnerID=8YFLogxK
M3 - Article
C2 - 3487928
AN - SCOPUS:0022530045
VL - 195 Pt A
SP - 81
EP - 83
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -