Adenosine deaminase deficiency and chondro-osseous dysplasia.

R. L. Wortmann, J. A. Veum, Herman S Cheung

Research output: Contribution to journalArticle

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Abstract

An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.

Original languageEnglish
Pages (from-to)81-83
Number of pages3
JournalAdvances in Experimental Medicine and Biology
Volume195 Pt A
StatePublished - Jan 1 1986
Externally publishedYes

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Adenosine Deaminase
Cartilage
Growth Plate
Poisons
Articular Cartilage
Metabolism
Toxicity
Adenosine Triphosphate
Rabbits
Enzymes
Severe combined immunodeficiency due to adenosine deaminase deficiency
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Adenosine deaminase deficiency and chondro-osseous dysplasia. / Wortmann, R. L.; Veum, J. A.; Cheung, Herman S.

In: Advances in Experimental Medicine and Biology, Vol. 195 Pt A, 01.01.1986, p. 81-83.

Research output: Contribution to journalArticle

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