Adenosine deaminase deficiency and chondro-osseous dysplasia.

R. L. Wortmann, J. A. Veum, H. S. Cheung

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.

Original languageEnglish (US)
Pages (from-to)81-83
Number of pages3
JournalAdvances in experimental medicine and biology
Volume195 Pt A
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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