Abstract
An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-83 |
| Number of pages | 3 |
| Journal | Advances in experimental medicine and biology |
| Volume | 195 Pt A |
| State | Published - Jan 1 1986 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Wortmann, R. L., Veum, J. A., & Cheung, H. S. (1986). Adenosine deaminase deficiency and chondro-osseous dysplasia. Advances in experimental medicine and biology, 195 Pt A, 81-83.