Abstract
An in vitro model of ADA deficiency is selectively toxic to cartilage from immature rabbits with a greater effect on growth plate than articular cartilage. The selective toxicity observed appears to be the consequence of ATP depletion. These results support the hypothesis that the chondro-osseous dysplasia observed in patients with ADA deficiency is caused by the disordered metabolism that results from the enzyme deficiency.
Original language | English (US) |
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Pages (from-to) | 81-83 |
Number of pages | 3 |
Journal | Advances in experimental medicine and biology |
Volume | 195 Pt A |
DOIs | |
State | Published - 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)