An animal model for the study of host-prostatic tumor cell interactions is the cell strain R-3327, a line of prostatic adenocarcinoma of the Copenhagen rat, which is immunogenic to its syngeneic host as evidenced by 2 different cell-mediated immune assays in vitro. Specificity of the responses was ascertained on the basis of absence of response: of nonimmune lymphocytes to the R-3327 tumor antigen(s); of R-3327 immune lymphocytes to several normal tissues including normal prostate; and of immune lymphocytes to unrelated squamous cell prostatic carcinoma of the Copenhagen rat. Furthermore, the presence of tumor has an effect in several nonspecific aspects of host response, inducing splenomegaly, heightened responses to nonspecific mitogens in lymphocyte transformation assay, and increased levels of killer cell action. Since there are many histological, biochemical, and functional analogies between this tumor line and human prostate carcinomas, this system appears to be suitable for immunologic and possible immunotherapeutic studies of this type of neoplasia.
|Original language||English (US)|
|State||Published - Dec 1 1977|
ASJC Scopus subject areas
- Cancer Research