Adenocarcinoma arising from a strictureplasty site in Crohn's disease: Report of a case

Floriano Marchetti, Victor W. Fazio, Gokhan Ozuner

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


The occurrence of small-bowel cancer in Crohn's disease (CD) is a rare event. The risk seems to be greatest in patients with long-standing disease. Strictureplasty has proved to be a valuable alternative in the management of Crohn's strictures of the small-bowel. Critics and proponents of strictureplasty for selected patients with small-bowel Crohn's disease have voiced their concerns about cancer risk in the strictured or strictureplasty site. To date, there has been no clear or detailed report of such an occurrence. The authors report the first case of small-bowel adenocarcinoma arising at the site of a previous strictureplasty. In this patient, biopsies of the strictures at the original operation confirmed CD and excluded both cancer and dysplasia. Malignancy occurred seven years later at a strictureplasty site. The main clinical sign associated with the adenocarcinoma was severe, persistent anemia. The authors conclude that the risk of adenocarcinoma developing at the site of a previous strictureplasty for CD, although small, is real.

Original languageEnglish (US)
Pages (from-to)1315-1321
Number of pages7
JournalDiseases of the Colon and Rectum
Issue number11
StatePublished - Jan 1 1996
Externally publishedYes


  • Crohn's disease
  • Small-bowel adenocarcinoma
  • Strictureplasty

ASJC Scopus subject areas

  • Gastroenterology


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