Abstract
Background: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are increasingly recognized in clinical practice. There are no published data suggesting a management approach for the potential organ transplant recipient with the incidental finding of this pre-malignant lesion. Method: The recipient was a 65-yr-old man with hepatocellular carcinoma in a background of Laennec's cirrhosis. During evaluation for transplant, he was found to have diffuse IPMN. This patient underwent liver transplantation with a planned simultaneous total native pancreatectomy and pancreas transplant from the same donor. Results: The patient has had normal liver function and has been free of diabetes and exocrine insufficiency at 18 months post-transplant. Conclusion: IPMN in the potential transplant recipient should be managed more aggressively than in the general population because these patients will be committed to life-long immunosuppression. If a total pancreatectomy is contemplated, this is a unique opportunity to replace the pancreas with an allograft at the time of transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 681-684 |
| Number of pages | 4 |
| Journal | Clinical Transplantation |
| Volume | 22 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Transplantation
Cite this
Addition of a total pancreatectomy and pancreas transplantation in a liver transplant recipient with intraductal papillary mucinous neoplasm of the pancreas. / Fridell, Jonathan A.; Vianna, Rodrigo; Mangus, Richard S.; Kazimi, Marwan; Hollinger, Edward; Joseph Tector, A.
In: Clinical Transplantation, Vol. 22, No. 5, 2008, p. 681-684.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Addition of a total pancreatectomy and pancreas transplantation in a liver transplant recipient with intraductal papillary mucinous neoplasm of the pancreas
AU - Fridell, Jonathan A.
AU - Vianna, Rodrigo
AU - Mangus, Richard S.
AU - Kazimi, Marwan
AU - Hollinger, Edward
AU - Joseph Tector, A.
PY - 2008
Y1 - 2008
N2 - Background: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are increasingly recognized in clinical practice. There are no published data suggesting a management approach for the potential organ transplant recipient with the incidental finding of this pre-malignant lesion. Method: The recipient was a 65-yr-old man with hepatocellular carcinoma in a background of Laennec's cirrhosis. During evaluation for transplant, he was found to have diffuse IPMN. This patient underwent liver transplantation with a planned simultaneous total native pancreatectomy and pancreas transplant from the same donor. Results: The patient has had normal liver function and has been free of diabetes and exocrine insufficiency at 18 months post-transplant. Conclusion: IPMN in the potential transplant recipient should be managed more aggressively than in the general population because these patients will be committed to life-long immunosuppression. If a total pancreatectomy is contemplated, this is a unique opportunity to replace the pancreas with an allograft at the time of transplantation.
AB - Background: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are increasingly recognized in clinical practice. There are no published data suggesting a management approach for the potential organ transplant recipient with the incidental finding of this pre-malignant lesion. Method: The recipient was a 65-yr-old man with hepatocellular carcinoma in a background of Laennec's cirrhosis. During evaluation for transplant, he was found to have diffuse IPMN. This patient underwent liver transplantation with a planned simultaneous total native pancreatectomy and pancreas transplant from the same donor. Results: The patient has had normal liver function and has been free of diabetes and exocrine insufficiency at 18 months post-transplant. Conclusion: IPMN in the potential transplant recipient should be managed more aggressively than in the general population because these patients will be committed to life-long immunosuppression. If a total pancreatectomy is contemplated, this is a unique opportunity to replace the pancreas with an allograft at the time of transplantation.
UR - http://www.scopus.com/inward/record.url?scp=52649145308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52649145308&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0012.2008.00863.x
DO - 10.1111/j.1399-0012.2008.00863.x
M3 - Article
C2 - 18627400
AN - SCOPUS:52649145308
VL - 22
SP - 681
EP - 684
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
IS - 5
ER -