Adaptive activation of thyroid hormone and energy expenditure

Antonio C. Bianco, Ana Luiza Maia, Wagner Seixas Da Silva, Marcelo A. Christoffolete

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations


The mechanisms by which thyroid hormone accelerates energy expenditure are poorly understood. In the brown adipose tissue (BAT), activation of thyroid hormone by type 2 iodothyronine deiodinase (D2) has been known to play a role in adaptive energy expenditure during cold exposure in human newborns and other small mammals. Although BAT is not present in significant amounts in normal adult humans, recent studies have found substantial amounts of D2 in skeletal muscle, a metabolically relevant tissue in humans. This article reviews current biological knowledge about D2 and adaptive T3 production and their roles in energy expenditure.

Original languageEnglish (US)
Pages (from-to)191-208
Number of pages18
JournalBioscience reports
Issue number3-4
StatePublished - Jun 2005


  • Brown adipose tissue
  • Deiodinase
  • Skeletal muscle
  • Uncoupling protien

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology


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