Abstract
Intracerebrally-administered neurotensin produces a marked hypothermia in a variety of mammals. In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered neurotensin in mice. This antagonism required both previous exposure to cold ambient temperatures and cold exposure immediately prior to, or simultaneously with, neurotensin administration. The antagonism of neurotensin-induced hypothermia by prior cold-adaptation was blocked by indomethacin, but not by acetylsalicylic acid, suggesting that brain prostaglandin synthesis may be essential for this newly-discovered phenomenon.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 136-142 |
| Number of pages | 7 |
| Journal | Brain research |
| Volume | 369 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Mar 26 1986 |
Keywords
- cold adaptation
- hypothermia
- neurotensin
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
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Cite this
Merritt, W. D., Bissette, G., Luttinger, D., Prange, A. J., & Nemeroff, C. B. (1986). Adaptation to cold antagonizes neurotensin-induced hypothermia in mice. Brain research, 369(1-2), 136-142. https://doi.org/10.1016/0006-8993(86)90521-4