Abstract
Intracerebrally-administered neurotensin produces a marked hypothermia in a variety of mammals. In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered neurotensin in mice. This antagonism required both previous exposure to cold ambient temperatures and cold exposure immediately prior to, or simultaneously with, neurotensin administration. The antagonism of neurotensin-induced hypothermia by prior cold-adaptation was blocked by indomethacin, but not by acetylsalicylic acid, suggesting that brain prostaglandin synthesis may be essential for this newly-discovered phenomenon.
Original language | English (US) |
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Pages (from-to) | 136-142 |
Number of pages | 7 |
Journal | Brain research |
Volume | 369 |
Issue number | 1-2 |
DOIs | |
State | Published - Mar 26 1986 |
Externally published | Yes |
Keywords
- cold adaptation
- hypothermia
- neurotensin
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)