Adaptation to cold antagonizes neurotensin-induced hypothermia in mice

W. Davis Merritt, Garth Bissette, Daniel Luttinger, Arthur J. Prange, Charles B. Nemeroff

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Intracerebrally-administered neurotensin produces a marked hypothermia in a variety of mammals. In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered neurotensin in mice. This antagonism required both previous exposure to cold ambient temperatures and cold exposure immediately prior to, or simultaneously with, neurotensin administration. The antagonism of neurotensin-induced hypothermia by prior cold-adaptation was blocked by indomethacin, but not by acetylsalicylic acid, suggesting that brain prostaglandin synthesis may be essential for this newly-discovered phenomenon.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalBrain research
Volume369
Issue number1-2
DOIs
StatePublished - Mar 26 1986

Keywords

  • cold adaptation
  • hypothermia
  • neurotensin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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