Adaptation to cold antagonizes neurotensin-induced hypothermia in mice

W. Davis Merritt, Garth Bissette, Daniel Luttinger, Arthur J. Prange, Charles Nemeroff

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Intracerebrally-administered neurotensin produces a marked hypothermia in a variety of mammals. In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered neurotensin in mice. This antagonism required both previous exposure to cold ambient temperatures and cold exposure immediately prior to, or simultaneously with, neurotensin administration. The antagonism of neurotensin-induced hypothermia by prior cold-adaptation was blocked by indomethacin, but not by acetylsalicylic acid, suggesting that brain prostaglandin synthesis may be essential for this newly-discovered phenomenon.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalBrain Research
Volume369
Issue number1-2
DOIs
StatePublished - Mar 26 1986
Externally publishedYes

Fingerprint

Induced Hypothermia
Neurotensin
Hypothermia
Indomethacin
Aspirin
Prostaglandins
Mammals
Brain

Keywords

  • cold adaptation
  • hypothermia
  • neurotensin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Adaptation to cold antagonizes neurotensin-induced hypothermia in mice. / Merritt, W. Davis; Bissette, Garth; Luttinger, Daniel; Prange, Arthur J.; Nemeroff, Charles.

In: Brain Research, Vol. 369, No. 1-2, 26.03.1986, p. 136-142.

Research output: Contribution to journal › Article

Merritt, WD, Bissette, G, Luttinger, D, Prange, AJ & Nemeroff, C 1986, 'Adaptation to cold antagonizes neurotensin-induced hypothermia in mice', Brain Research, vol. 369, no. 1-2, pp. 136-142. https://doi.org/10.1016/0006-8993(86)90521-4
Merritt WD, Bissette G, Luttinger D, Prange AJ, Nemeroff C. Adaptation to cold antagonizes neurotensin-induced hypothermia in mice. Brain Research. 1986 Mar 26;369(1-2):136-142. https://doi.org/10.1016/0006-8993(86)90521-4
Merritt, W. Davis ; Bissette, Garth ; Luttinger, Daniel ; Prange, Arthur J. ; Nemeroff, Charles. / Adaptation to cold antagonizes neurotensin-induced hypothermia in mice. In: Brain Research. 1986 ; Vol. 369, No. 1-2. pp. 136-142.
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