AD gene 3-D: Moving past single layer genetic information to map novel loci involved in alzheimer's disease

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Over the past 5 years, there has been considerable advancement in the genetics of Alzheimer's disease. This review will provide an overview of the current state of the field for analysis of genetic variation and Alzheimer's disease. Highlighted in this review will be the results from some of the more conventional approaches, including linkage and association studies, as well as an overview of an alternate approach: eQTL analysis. The emphasis will be on taking genomics to the next level by applying additional datasets to truly create maps of a 3-dimensional Alzheimer's genome by including the downstream effects of risk variation.

Original languageEnglish (US)
Title of host publicationAlzheimer's Disease
Subtitle of host publicationAdvances for a New Century
PublisherIOS Press
Pages15-22
Number of pages8
ISBN (Electronic)9781614991540
ISBN (Print)9781614991533
DOIs
StatePublished - Feb 15 2013

Keywords

  • Alzheimer's disease
  • EQTL
  • Expression quantitative trait locus
  • Gene expression
  • Gene expression regulation
  • Genetic
  • Genetic predisposition to disease
  • Human brain
  • Transcription

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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