AD gene 3-D

Moving past single layer genetic information to map novel loci involved in Alzheimer's disease

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Over the past 5 years, there has been considerable advancement in the genetics of Alzheimer's disease. This review will provide an overview of the current state of the field for analysis of genetic variation and Alzheimer's disease. Highlighted in this review will be the results from some of the more conventional approaches, including linkage and association studies, as well as an overview of an alternate approach: eQTL analysis. The emphasis will be on taking genomics to the next level by applying additional datasets to truly create maps of a 3-dimensional Alzheimer's genome by including the downstream effects of risk variation.

Original languageEnglish
JournalJournal of Alzheimer's Disease
Volume33
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 24 2013

Fingerprint

Inborn Genetic Diseases
Alzheimer Disease
Genomics
Genes
Genome
Datasets

Keywords

  • Alzheimer's disease
  • eQTL
  • expression quantitative trait locus
  • gene expression
  • gene expression regulation
  • genetic
  • genetic predisposition to disease
  • human brain
  • transcription

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

@article{eef2d70d799f4a0281c4c61ca11fd54a,
title = "AD gene 3-D: Moving past single layer genetic information to map novel loci involved in Alzheimer's disease",
abstract = "Over the past 5 years, there has been considerable advancement in the genetics of Alzheimer's disease. This review will provide an overview of the current state of the field for analysis of genetic variation and Alzheimer's disease. Highlighted in this review will be the results from some of the more conventional approaches, including linkage and association studies, as well as an overview of an alternate approach: eQTL analysis. The emphasis will be on taking genomics to the next level by applying additional datasets to truly create maps of a 3-dimensional Alzheimer's genome by including the downstream effects of risk variation.",
keywords = "Alzheimer's disease, eQTL, expression quantitative trait locus, gene expression, gene expression regulation, genetic, genetic predisposition to disease, human brain, transcription",
author = "Myers, {Amanda J}",
year = "2013",
month = "1",
day = "24",
doi = "10.3233/JAD-2012-129013",
language = "English",
volume = "33",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "SUPPL. 1",

}

TY - JOUR

T1 - AD gene 3-D

T2 - Moving past single layer genetic information to map novel loci involved in Alzheimer's disease

AU - Myers, Amanda J

PY - 2013/1/24

Y1 - 2013/1/24

N2 - Over the past 5 years, there has been considerable advancement in the genetics of Alzheimer's disease. This review will provide an overview of the current state of the field for analysis of genetic variation and Alzheimer's disease. Highlighted in this review will be the results from some of the more conventional approaches, including linkage and association studies, as well as an overview of an alternate approach: eQTL analysis. The emphasis will be on taking genomics to the next level by applying additional datasets to truly create maps of a 3-dimensional Alzheimer's genome by including the downstream effects of risk variation.

AB - Over the past 5 years, there has been considerable advancement in the genetics of Alzheimer's disease. This review will provide an overview of the current state of the field for analysis of genetic variation and Alzheimer's disease. Highlighted in this review will be the results from some of the more conventional approaches, including linkage and association studies, as well as an overview of an alternate approach: eQTL analysis. The emphasis will be on taking genomics to the next level by applying additional datasets to truly create maps of a 3-dimensional Alzheimer's genome by including the downstream effects of risk variation.

KW - Alzheimer's disease

KW - eQTL

KW - expression quantitative trait locus

KW - gene expression

KW - gene expression regulation

KW - genetic

KW - genetic predisposition to disease

KW - human brain

KW - transcription

UR - http://www.scopus.com/inward/record.url?scp=84872526808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872526808&partnerID=8YFLogxK

U2 - 10.3233/JAD-2012-129013

DO - 10.3233/JAD-2012-129013

M3 - Article

VL - 33

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - SUPPL. 1

ER -