ACYCLOVIR THERAPY FOR MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS IN IMMUNOCOMPROMISED PATIENTS

Charles D. Mitchell; Sharron R. Gentry; James R. Boen; Bonnie Bean; Karl E. Groth; Henry H. Balfour

doi:10.1016/S0140-6736(81)92569-1

ACYCLOVIR THERAPY FOR MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS IN IMMUNOCOMPROMISED PATIENTS

Charles D. Mitchell, Sharron R. Gentry, James R. Boen, Bonnie Bean, Karl E. Groth, Henry H. Balfour

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

11 of 24 immunocompromised patients with mucocutaneous herpes simplex virus (HSV) infections were given intravenous acyclovir in a randomised double-blind placebo-controlled study. Patients receiving acyclovir experienced no major adverse effects. The median times to cessation of new lesion formation, lesion crusting, lesion healing, cessation of pain, and termination of viral shedding were shorter in the acyclovir-treated group than in the placebo group. The time-to-event probability curves for the acyclovir and placebo groups were significantly different for cessation of pain (p = 0.032) and termination of viral shedding (p = 0.004). The median times to termination of viral shedding were also statistically different (p = 0.045). Acyclovir seems to be a non-toxic and effective treatment for mucocutaneous HSV infections in immunocompromised patients.

Original language	English (US)
Pages (from-to)	1389-1392
Number of pages	4
Journal	The Lancet
Volume	317
Issue number	8235
DOIs	https://doi.org/10.1016/S0140-6736(81)92569-1
State	Published - Jun 27 1981
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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@article{080c7939b45b4380a445ab51d7421fdf,

title = "ACYCLOVIR THERAPY FOR MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS IN IMMUNOCOMPROMISED PATIENTS",

abstract = "11 of 24 immunocompromised patients with mucocutaneous herpes simplex virus (HSV) infections were given intravenous acyclovir in a randomised double-blind placebo-controlled study. Patients receiving acyclovir experienced no major adverse effects. The median times to cessation of new lesion formation, lesion crusting, lesion healing, cessation of pain, and termination of viral shedding were shorter in the acyclovir-treated group than in the placebo group. The time-to-event probability curves for the acyclovir and placebo groups were significantly different for cessation of pain (p = 0.032) and termination of viral shedding (p = 0.004). The median times to termination of viral shedding were also statistically different (p = 0.045). Acyclovir seems to be a non-toxic and effective treatment for mucocutaneous HSV infections in immunocompromised patients.",

author = "Mitchell, {Charles D.} and Gentry, {Sharron R.} and Boen, {James R.} and Bonnie Bean and Groth, {Karl E.} and Balfour, {Henry H.}",

note = "Funding Information: in part by grants AM 13083 and AM 18883 from the National Institutes of Health, and by a grant from Burroughs Wellcome Company, U.S.A.",

year = "1981",

month = jun,

day = "27",

doi = "10.1016/S0140-6736(81)92569-1",

language = "English (US)",

volume = "317",

pages = "1389--1392",

journal = "The Lancet",

issn = "0140-6736",

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number = "8235",

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T1 - ACYCLOVIR THERAPY FOR MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS IN IMMUNOCOMPROMISED PATIENTS

AU - Mitchell, Charles D.

AU - Gentry, Sharron R.

AU - Boen, James R.

AU - Bean, Bonnie

AU - Groth, Karl E.

AU - Balfour, Henry H.

N1 - Funding Information: in part by grants AM 13083 and AM 18883 from the National Institutes of Health, and by a grant from Burroughs Wellcome Company, U.S.A.

PY - 1981/6/27

Y1 - 1981/6/27

N2 - 11 of 24 immunocompromised patients with mucocutaneous herpes simplex virus (HSV) infections were given intravenous acyclovir in a randomised double-blind placebo-controlled study. Patients receiving acyclovir experienced no major adverse effects. The median times to cessation of new lesion formation, lesion crusting, lesion healing, cessation of pain, and termination of viral shedding were shorter in the acyclovir-treated group than in the placebo group. The time-to-event probability curves for the acyclovir and placebo groups were significantly different for cessation of pain (p = 0.032) and termination of viral shedding (p = 0.004). The median times to termination of viral shedding were also statistically different (p = 0.045). Acyclovir seems to be a non-toxic and effective treatment for mucocutaneous HSV infections in immunocompromised patients.

AB - 11 of 24 immunocompromised patients with mucocutaneous herpes simplex virus (HSV) infections were given intravenous acyclovir in a randomised double-blind placebo-controlled study. Patients receiving acyclovir experienced no major adverse effects. The median times to cessation of new lesion formation, lesion crusting, lesion healing, cessation of pain, and termination of viral shedding were shorter in the acyclovir-treated group than in the placebo group. The time-to-event probability curves for the acyclovir and placebo groups were significantly different for cessation of pain (p = 0.032) and termination of viral shedding (p = 0.004). The median times to termination of viral shedding were also statistically different (p = 0.045). Acyclovir seems to be a non-toxic and effective treatment for mucocutaneous HSV infections in immunocompromised patients.

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VL - 317

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EP - 1392

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8235

ER -

ACYCLOVIR THERAPY FOR MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS IN IMMUNOCOMPROMISED PATIENTS

Abstract

ASJC Scopus subject areas

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