An experimental model for measuring effects of various pharmacologic agents on results of acute trauma in the canine ureter is described. The effects of two agents, low molecular weight dextran and Pluronic F-68, a nonionic detergent, were measured on this model. Neither agent was found to affect the formation of post-traumatic edema. After acute high-dose administration of Pluronic F-68 no toxicity was detected in either kidney or bladder.
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